iPTMnet Report for Q86VP3 (PACS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86VP3 / PACS2_HUMAN
Protein Name Phosphofurin acidic cluster sorting protein 2
Gene Name Name: PACS2
Synonyms:KIAA0602,PACS1L;
Organism Homo sapiens (Human)

PRO ID PR:Q86VP3
DAG View
PRO Name phosphofurin acidic cluster sorting protein 2 (human)
Definition A phosphofurin acidic cluster sorting protein 2 that is encoded in the genome of human.
Short Label hPACS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86VP3 (PACS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S43 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S349 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S366 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
T414 O-Glycosylation GlyGen 30379171, 34019948, 28657654
T414 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T422 O-Glycosylation GlyGen 30379171, 34019948, 28657654
T436 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus   RLIMS-P 19481529, 23852728
S437 Phosphorylation P31749 (AKT1) PhosphoSitePlus 23852728
S453 Phosphorylation PhosphoSitePlus   UniProt 24275569
S464 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
T722 Phosphorylation PhosphoSitePlus
K766 Acetylation PhosphoSitePlus
K767 Acetylation PhosphoSitePlus
K773 Acetylation PhosphoSitePlus
K777 Acetylation PhosphoSitePlus
T806 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S390 Phosphorylation HPRD 20068231
S437 Phosphorylation PRO 19481529
S790 Phosphorylation HPRD 20068231
T806 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044817 (hPACS2/Phos:1) pS437 PRO 19481529


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P27824 (CANX) S564 Q86VP3 (PACS2) decreased_association eFIP 18417615


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000044817 (hPACS2/Phos:1) Interaction PR:000044507 (fam:14-3-3 (human)) PRO 19481529


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S208 P208 Biomuta DOID:363 / uterine cancer [ icgc ]
S208 F208 Biomuta DOID:4159 / skin cancer [ cosmic ]
S238 L238 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S244 F244 Biomuta DOID:4159 / skin cancer [ cosmic ]
T246 I246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S331 L331 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S416 F416 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S437 F437 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S453 I453 Biomuta DOID:1324 / lung cancer [ cosmic ]