iPTMnet Report for Q86VM9 (ZC3H18)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86VM9 / ZCH18_HUMAN
Protein Name Zinc finger CCCH domain-containing protein 18
Gene Name Name: ZC3H18
Synonyms:NHN1;
Organism Homo sapiens (Human)

PRO ID PR:Q86VM9
DAG View
PRO Name zinc finger CCCH domain-containing protein 18 (human)
Definition A zinc finger CCCH domain-containing protein 18 that is encoded in the genome of human.
Short Label hZC3H18
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86VM9 (ZC3H18) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 21406692
S6 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692, 23186163, ...20068231
S13 Phosphorylation HPRD   PhosphoSitePlus 18452278
S24 Phosphorylation HPRD   PhosphoSitePlus 18452278
S32 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231, 18452278
S34 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 15302935, 24275569, ...18452278
S46 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 18212344, ...15302935, 18452278, 19651622, 19367720, 18669648, 24275569, 19690332, 20068231, 17081983
S53 Phosphorylation PhosphoSitePlus   UniProt 24275569
S59 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231, 18452278
S67 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18077418, 18452278, ...19651622, 18669648
S74 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18077418, 18452278, ...19651622, 18669648, 20068231
S78 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18077418, 19664994, 18452278, 19651622, 18669648, 20068231
S83 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18452278, 19651622, 20068231
S89 Phosphorylation HPRD   PhosphoSitePlus 18452278
T93 Phosphorylation HPRD 18669648
S94 Phosphorylation HPRD   PhosphoSitePlus 18669648, 18452278
S95 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
T109 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 18452278
S110 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 18452278
S117 Phosphorylation PhosphoSitePlus
S118 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T120 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
T162 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S173 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S179 Phosphorylation PhosphoSitePlus   UniProt 23186163
K229 Methylation PhosphoSitePlus
R239 Methylation PhosphoSitePlus
K248 Methylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus
Y371 Phosphorylation PhosphoSitePlus
Y372 Phosphorylation PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
R381 Methylation PhosphoSitePlus
Y385 Phosphorylation PhosphoSitePlus
Y392 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
Y398 Phosphorylation PhosphoSitePlus
K480 Acetylation PhosphoSitePlus
K482 Acetylation PhosphoSitePlus
S487 Phosphorylation HPRD   PhosphoSitePlus   UniProt 15302935, 17287340, 20068231, ...23186163
S492 Phosphorylation HPRD   PhosphoSitePlus 20068231
K510 Methylation PhosphoSitePlus
K510 Sumoylation PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
K528 Sumoylation PhosphoSitePlus
S532 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 16964243, ...18691976, 15302935, 19651622, 18669648, 19415658, 20068231
S534 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18212344, 18691976, 16964243, 18767875, 19664994, 20058876, 19664995, 18452278, 19651622, 15302935, 18669648, 24275569, 20166139, 17924679, 19415658, 20068231, 20068230
S536 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...20058876, 19651622, 18767875, 20068231
S545 Phosphorylation PhosphoSitePlus
S547 Phosphorylation HPRD   PhosphoSitePlus 15302935
S552 Phosphorylation HPRD   PhosphoSitePlus 15302935
S558 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
S587 Phosphorylation HPRD   PhosphoSitePlus 18452278
S590 Phosphorylation HPRD   PhosphoSitePlus 18452278
S591 Phosphorylation PhosphoSitePlus
S595 Phosphorylation HPRD   PhosphoSitePlus 18452278
S597 Phosphorylation PhosphoSitePlus
S604 Phosphorylation HPRD   PhosphoSitePlus 19651622
S609 Phosphorylation HPRD 19651622
T611 Phosphorylation PhosphoSitePlus
S613 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 19651622, 18847512
S618 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K622 Sumoylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
K639 Sumoylation PhosphoSitePlus
T653 Phosphorylation HPRD   PhosphoSitePlus 20068230
K661 Acetylation PhosphoSitePlus
K661 Sumoylation PhosphoSitePlus
T677 Phosphorylation HPRD   PhosphoSitePlus 20068231
T683 Phosphorylation PhosphoSitePlus
S685 Phosphorylation HPRD   PhosphoSitePlus 19664995
S689 Phosphorylation HPRD   PhosphoSitePlus 20068231
S694 Phosphorylation HPRD 20068231
Y695 Phosphorylation HPRD 20068231
S699 Phosphorylation PhosphoSitePlus
S700 Phosphorylation HPRD 20068231
S737 Phosphorylation HPRD 20068231
S743 Phosphorylation HPRD 20068231
S744 Phosphorylation HPRD 20068231
S746 Phosphorylation HPRD   PhosphoSitePlus 15302935, 20068231
T752 Phosphorylation HPRD 20068231
K766 Acetylation PhosphoSitePlus
K766 Sumoylation PhosphoSitePlus
S774 Phosphorylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
T776 Phosphorylation PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
K783 Acetylation PhosphoSitePlus
S795 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 18847512, 19664995, 20068231
T796 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 18669648, 18491316, 18847512
T809 Phosphorylation PhosphoSitePlus
K814 Acetylation PhosphoSitePlus
K817 Acetylation PhosphoSitePlus
K817 Sumoylation PhosphoSitePlus
K823 Sumoylation PhosphoSitePlus
Y833 Phosphorylation PhosphoSitePlus
S842 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 18452278, ...19651622, 24275569, 20068231
T851 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231, 18691976
S852 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231, 18452278
S857 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S862 Phosphorylation PhosphoSitePlus
S868 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 19664995, 18452278, 19651622, 18707149, 20166139, 17924679, 19415658, 20068231, 18212344
R875 Methylation PhosphoSitePlus
S893 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
S896 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 20068231
K901 Sumoylation PhosphoSitePlus
K908 Sumoylation PhosphoSitePlus
S910 Phosphorylation PhosphoSitePlus
K921 Acetylation PhosphoSitePlus
K921 Sumoylation PhosphoSitePlus
K952 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S13 C13 Biomuta DOID:4159 / skin cancer [ cosmic ]
S34 F34 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S67 C67 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S74 N74 Biomuta DOID:10283 / prostate cancer [ icgc ]
S179 F179 Biomuta DOID:4159 / skin cancer [ cosmic ]
R239 M239 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S252 F252 Biomuta DOID:4159 / skin cancer [ cosmic ]
R381 C381 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R381 H381 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K516 R516 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K516 N516 Biomuta DOID:3571 / liver cancer [ cosmic, icgc, tcga ]
S545 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S547 L547 Biomuta DOID:4159 / skin cancer [ cosmic ]
S552 F552 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S558 F558 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S591 L591 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S591 P591 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S604 L604 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
S609 C609 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S618 F618 Biomuta DOID:4159 / skin cancer [ cosmic ]
S700 F700 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S744 F744 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S774 L774 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T851 K851 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S862 L862 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
K901 R901 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S910 L910 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]