iPTMnet Report for Q86VI3 (IQGAP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86VI3 / IQGA3_HUMAN
Protein Name Ras GTPase-activating-like protein IQGAP3
Gene Name Name: IQGAP3
Organism Homo sapiens (Human)

PRO ID PR:Q86VI3
DAG View
PRO Name Ras GTPase-activating-like protein IQGAP3 (human)
Definition A Ras GTPase-activating-like protein IQGAP3 that is encoded in the genome of human.
Short Label hIQGAP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86VI3 (IQGAP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y13 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
Y140 Phosphorylation HPRD 20068231
K164 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
T168 Phosphorylation PhosphoSitePlus
S201 O-Glycosylation GlyGen 30379171, 29351928
S201 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
R324 Methylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K398 Methylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S539 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
K542 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
T628 Phosphorylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
K938 Acetylation PhosphoSitePlus
K943 Ubiquitination PhosphoSitePlus
S944 O-Glycosylation GlyGen 30379171, 29351928
K947 Acetylation PhosphoSitePlus
K949 Acetylation PhosphoSitePlus
K981 Ubiquitination PhosphoSitePlus
K1011 Acetylation PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
T1012 Phosphorylation PhosphoSitePlus
K1019 Ubiquitination PhosphoSitePlus
K1021 Ubiquitination PhosphoSitePlus
K1067 Ubiquitination PhosphoSitePlus
K1080 Acetylation PhosphoSitePlus
K1080 Ubiquitination PhosphoSitePlus
Y1098 Phosphorylation PhosphoSitePlus
T1101 Phosphorylation PhosphoSitePlus
T1134 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation HPRD 17081983
S1136 Phosphorylation HPRD 17081983
K1152 Ubiquitination PhosphoSitePlus
K1158 Ubiquitination PhosphoSitePlus
K1169 Ubiquitination PhosphoSitePlus
K1245 Ubiquitination PhosphoSitePlus
Y1268 Phosphorylation PhosphoSitePlus
S1269 Phosphorylation PhosphoSitePlus
T1289 Phosphorylation PhosphoSitePlus
S1360 Phosphorylation HPRD   PhosphoSitePlus 20166139
T1362 Phosphorylation HPRD   PhosphoSitePlus 20166139
K1370 Ubiquitination PhosphoSitePlus
K1402 Ubiquitination PhosphoSitePlus
T1412 Phosphorylation PhosphoSitePlus
T1415 Phosphorylation HPRD   PhosphoSitePlus 18691976
S1424 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18452278, ...18669648, 20068231
T1426 Phosphorylation HPRD   PhosphoSitePlus 19651622
S1429 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1436 Ubiquitination PhosphoSitePlus
S1509 Phosphorylation PhosphoSitePlus
S1523 Phosphorylation PhosphoSitePlus
K1524 Ubiquitination PhosphoSitePlus
S1525 Phosphorylation PhosphoSitePlus
S1526 Phosphorylation PhosphoSitePlus
K1531 Ubiquitination PhosphoSitePlus
Y1537 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
T1538 Phosphorylation PhosphoSitePlus
K1545 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K70 N70 Biomuta DOID:1324 / lung cancer [ cosmic ]
R324 Q324 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K345 N345 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S944 L944 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1136 F1136 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1152 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1289 M1289 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1402 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1424 L1424 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1429 F1429 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1537 F1537 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]