iPTMnet Report for Q86V21 (AACS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86V21 / AACS_HUMAN
Protein Name Acetoacetyl-CoA synthetase
Gene Name Name: AACS
Synonyms:ACSF1;
Organism Homo sapiens (Human)

PRO ID PR:Q86V21
DAG View
PRO Name acetoacetyl-CoA synthetase (human)
Definition An acetoacetyl-CoA synthetase that is encoded in the genome of human.
Short Label hAACS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86V21 (AACS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K85 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
Y212 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
C329 Methylation IEDB 31844290
S412 Phosphorylation PhosphoSitePlus
C425 Methylation IEDB 31844290
K489 Ubiquitination PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
Y524 Phosphorylation PhosphoSitePlus
K530 Ubiquitination PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
Y578 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
K646 Acetylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
T659 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y212 Phosphorylation HPRD 19415658


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K85 E85 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K95 E95 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S412 F412 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
C425 F425 Biomuta DOID:3571 / liver cancer [ cosmic ]
K530 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S618 N618 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]