iPTMnet Report for Q86V20 (SHLD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86V20 / SHLD2_HUMAN
Protein Name Shieldin complex subunit 2
Gene Name Name: SHLD2
Synonyms:FAM35A;
Organism Homo sapiens (Human)

PRO ID PR:Q86V20
DAG View
PRO Name shieldin complex subunit 2 (human)
Definition A shieldin complex subunit 2 that is encoded in the genome of human.
Short Label hSHLD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86V20 (SHLD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K63 Ubiquitination PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
S339 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 29789392
K385 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
T473 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
Y567 Phosphorylation PhosphoSitePlus
K622 Acetylation PhosphoSitePlus
K653 Acetylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S339 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
K703 Ubiquitination PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S109 C109 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S465 A465 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S792 I792 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]