iPTMnet Report for Q86UW9 (DTX2)
Protein Information
| UniProt AC / UniProt ID | Q86UW9 / DTX2_HUMAN |
| Protein Name | Probable E3 ubiquitin-protein ligase DTX2 |
| Gene Name | Name: DTX2 Synonyms:KIAA1528,RNF58; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q86UW9 |
| PRO Name | probable E3 ubiquitin-protein ligase DTX2 (human) |
| Definition | A protein deltex-2 that is encoded in the genome of human. |
| Short Label | hDTX2 |
| Category | organism-gene |
DAG ViewQ86UW9 (DTX2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y75 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T153 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y156 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R213 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
| R215 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
| S217 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R233 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
| S236 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y247 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K249 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K249 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S251 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S253 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R256 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
| S257 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y280 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R281 | Methylation | score1 | PhosphoSitePlus | |||
| C351 | Methylation | score1 | IEDB | 31844290 | ||
| S360 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
| S364 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S368 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K369 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S373 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K379 | Acetylation | score1 | PhosphoSitePlus | |||
| K383 | Acetylation | score1 | PhosphoSitePlus | |||
| T386 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K398 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K473 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K479 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K553 | Acetylation | score1 | PhosphoSitePlus | |||
| K553 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K557 | Acetylation | score2 | IEDB PhosphoSitePlus | 34357683 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S360 | Phosphorylation | score0 | HPRD | 18669648 | ||
| Y425 | Phosphorylation | score0 | HPRD | 18083107 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K341 | Sumoylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| R213 | C213 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic, icgc ] | |
| R213 | H213 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ icgc ] | |
| R215 | H215 | Biomuta | [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| S236 | F236 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Y247 | F247 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y247 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| R256 | Q256 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
| R281 | H281 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| C351 | Y351 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
| C351 | R351 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S364 | F364 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] |
