iPTMnet Report for Q86UU0 (BCL9L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86UU0 / BCL9L_HUMAN
Protein Name B-cell CLL/lymphoma 9-like protein
Gene Name Name: BCL9L
Synonyms:DLNB11;
Organism Homo sapiens (Human)

PRO ID PR:Q86UU0
DAG View
PRO Name B-cell CLL/lymphoma 9-like protein (human)
Definition A B-cell CLL/lymphoma 9-like protein that is encoded in the genome of human.
Short Label hBCL9L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86UU0 (BCL9L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 24275569
S25 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K36 Acetylation PhosphoSitePlus   UniProt 19608861
K43 Acetylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
C68 S-Nitrosylation dbSNO 26338901
K73 Acetylation PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...20068231
S93 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus   UniProt 19608861
K110 Acetylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus   UniProt 21406692
S118 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692
S121 Phosphorylation PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
K137 Acetylation PhosphoSitePlus   UniProt 19608861
T250 O-Glycosylation GlyGen 25813380
K275 Acetylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y465 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus   UniProt 23186163
K522 Sumoylation PhosphoSitePlus
Y527 Phosphorylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K534 Acetylation PhosphoSitePlus
R593 Methylation PhosphoSitePlus
R602 Methylation PhosphoSitePlus
R610 Methylation PhosphoSitePlus
R668 Methylation PhosphoSitePlus
R675 Methylation PhosphoSitePlus
R680 Methylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S813 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 18220336
R821 Methylation PhosphoSitePlus
S888 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053
S896 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053
S915 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 32245944
T918 Phosphorylation PhosphoSitePlus
S926 Phosphorylation PhosphoSitePlus
S934 Phosphorylation PhosphoSitePlus
T936 Phosphorylation PhosphoSitePlus
S938 Phosphorylation PhosphoSitePlus   UniProt 23186163
S942 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053
S942 Phosphorylation PhosphoSitePlus
T946 O-Glycosylation GlyGen 32938750, 35132862, 35254053, ...34019948, 31492838, 29351928, 30059200
T946 Phosphorylation PhosphoSitePlus
S947 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053
S947 Phosphorylation PhosphoSitePlus   UniProt 23186163
S949 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053
S949 Phosphorylation PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus
T957 Phosphorylation PhosphoSitePlus
S959 Phosphorylation PhosphoSitePlus
S975 Phosphorylation PhosphoSitePlus   UniProt 21406692
S987 Phosphorylation PhosphoSitePlus
T989 Phosphorylation PhosphoSitePlus
S991 Phosphorylation PhosphoSitePlus
S993 Phosphorylation PhosphoSitePlus
R994 Methylation PhosphoSitePlus
S997 Phosphorylation PhosphoSitePlus   UniProt 23186163
S999 Phosphorylation PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1010 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053
S1010 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
T1013 Phosphorylation PhosphoSitePlus
S1017 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S1021 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053
S1021 Phosphorylation PhosphoSitePlus
S1073 O-Glycosylation GlyGen 35132862, 30059200, 29351928, ...34019948, 31492838, 35254053
K1334 Acetylation PhosphoSitePlus
K1344 Sumoylation PhosphoSitePlus
R1439 Methylation PhosphoSitePlus
Y1446 Phosphorylation PhosphoSitePlus
S1447 Phosphorylation PhosphoSitePlus
S1454 Phosphorylation PhosphoSitePlus
S1458 Phosphorylation PhosphoSitePlus
S1478 Phosphorylation PhosphoSitePlus
S1480 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 19651622, 18669648, 20058876, ...17081983, 20068231
S25 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S88 Phosphorylation HPRD 19413330, 18669648, 16964243, ...20068231, 19664995
S93 Phosphorylation HPRD 18669648, 19664995, 20068231
S116 Phosphorylation HPRD 19651622
S118 Phosphorylation HPRD 19651622, 18669648
S410 Phosphorylation HPRD 20068231
S566 Phosphorylation HPRD 20068231
S750 Phosphorylation HPRD 19664995, 20068231
S813 Phosphorylation HPRD 18669648, 20068231
S915 Phosphorylation HPRD 17081983, 20068231
S920 Phosphorylation HPRD 20068231
S926 Phosphorylation HPRD 20068231
S934 Phosphorylation HPRD 19651622, 17081983, 20068231
T936 Phosphorylation HPRD 17081983
S938 Phosphorylation HPRD 18077418, 17081983
S942 Phosphorylation HPRD 19651622, 18077418, 19664994
T946 Phosphorylation HPRD 19651622, 18077418, 17081983
S947 Phosphorylation HPRD 19651622, 19664994, 17081983, ...20068231
S949 Phosphorylation HPRD 19651622, 17081983, 20068231
S954 Phosphorylation HPRD 19651622, 17081983, 20068231
T957 Phosphorylation HPRD 19651622, 17081983
S959 Phosphorylation HPRD 20068231
S975 Phosphorylation HPRD 19651622, 18767875, 19664994, ...20068231
S981 Phosphorylation HPRD 17081983
S982 Phosphorylation HPRD 17081983
S984 Phosphorylation HPRD 17081983, 20068231
S987 Phosphorylation HPRD 18669648, 17081983
T989 Phosphorylation HPRD 20068231
S991 Phosphorylation HPRD 18669648
S993 Phosphorylation HPRD 17081983
S997 Phosphorylation HPRD 19651622, 18669648, 20068231
S999 Phosphorylation HPRD 18669648, 17081983, 20068231
S1004 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S1010 Phosphorylation HPRD 18669648, 17081983, 20068231
S1017 Phosphorylation HPRD 19413330, 18669648, 19664994
S1478 Phosphorylation HPRD 20068231
S1480 Phosphorylation HPRD 18669648
S1483 Phosphorylation HPRD 17081983
Y1487 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35222 (CTNNB1) Y142 Q86UU0 (BCL9L) unknown eFIP 17052462


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S21 I21 Biomuta DOID:363 / uterine cancer [ icgc ]
K36 R36 Biomuta DOID:3571 / liver cancer [ cosmic ]
S106 L106 Biomuta DOID:4159 / skin cancer [ cosmic ]
S118 F118 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T250 M250 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S410 F410 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
Y465 F465 Biomuta DOID:1324 / lung cancer [ cosmic ]
T514 M514 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y527 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R593 W593 Biomuta DOID:4159 / skin cancer [ cosmic ]
R602 H602 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R610 W610 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R610 L610 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R668 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R668 Q668 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R675 C675 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ icgc ]
R680 W680 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
R680 Q680 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S813 N813 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R821 Q821 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R821 W821 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S888 R888 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S915 L915 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S926 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S926 L926 Biomuta DOID:4159 / skin cancer [ cosmic ]
S938 G938 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S947 L947 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S975 L975 Biomuta DOID:4159 / skin cancer [ cosmic ]
S981 F981 Biomuta DOID:4159 / skin cancer [ cosmic ]
S982 F982 Biomuta DOID:4159 / skin cancer [ cosmic ]
S991 L991 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S993 R993 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R994 M994 Biomuta DOID:1324 / lung cancer [ icgc ]
S999 F999 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1073 F1073 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1439 W1439 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1447 T1447 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1447 I1447 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1458 T1458 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1483 N1483 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]