Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86US8 / EST1A_HUMAN
Protein Name Telomerase-binding protein EST1A
Gene Name Name: SMG6
Synonyms:C17orf31,EST1A,KIAA0732;
Organism Homo sapiens (Human)

PRO ID PR:Q86US8
DAG View
PRO Name telomerase-binding protein EST1A (human)
Definition A telomerase-binding protein EST1A that is encoded in the genome of human.
Short Label hSMG6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86US8 (SMG6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus   UniProt 23186163
S240 Phosphorylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
T256 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
R404 Methylation PhosphoSitePlus
R406 Methylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
S438 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S440 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
R448 Methylation PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
T479 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S484 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T486 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
Y508 Phosphorylation PhosphoSitePlus
Y509 Phosphorylation PhosphoSitePlus
R512 Methylation PhosphoSitePlus
Y769 Phosphorylation PhosphoSitePlus
Y778 Phosphorylation PhosphoSitePlus
Y788 Phosphorylation PhosphoSitePlus
Y789 Phosphorylation PhosphoSitePlus
S796 Phosphorylation PhosphoSitePlus
K803 Acetylation PhosphoSitePlus
K814 Ubiquitination PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus   UniProt 23186163
S864 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
T868 Phosphorylation PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus   UniProt 23186163
S874 Phosphorylation PhosphoSitePlus   UniProt 23186163
S884 Phosphorylation PhosphoSitePlus
K918 Acetylation PhosphoSitePlus
K995 Ubiquitination PhosphoSitePlus
S1000 Phosphorylation PhosphoSitePlus
K1011 Ubiquitination PhosphoSitePlus
K1149 Ubiquitination PhosphoSitePlus
K1225 Ubiquitination PhosphoSitePlus
K1309 Ubiquitination PhosphoSitePlus
K1376 Ubiquitination PhosphoSitePlus
T1390 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation HPRD 20068231
S203 Phosphorylation HPRD 19413330
S438 Phosphorylation HPRD 18669648
T479 Phosphorylation HPRD 18669648
S484 Phosphorylation HPRD 18669648
Y509 Phosphorylation HPRD 15592455
S831 Phosphorylation HPRD 20068231
S1169 Phosphorylation HPRD 18767875


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q92900 (UPF1) T28 Q86US8 (SMG6) unknown eFIP 25013172
Phosphorylation Q92900 (UPF1) T28 Q86US8 (SMG6) unknown eFIP 21965535


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 F11 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S240 F240 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S297 P297 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
S332 F332 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S363 F363 Biomuta DOID:363 / uterine cancer [ tcga ]
R404 C404 Biomuta DOID:4362 / cervical cancer [ tcga ]
R406 C406 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S443 Y443 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T479 N479 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R512 L512 Biomuta DOID:363 / uterine cancer [ tcga ]
K814 N814 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T1390 M1390 Biomuta DOID:9256 / colorectal cancer [ icgc ]