Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86UL8 / MAGI2_HUMAN
Protein Name Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
Gene Name Name: MAGI2
Synonyms:ACVRINP1,AIP1,KIAA0705;
Organism Homo sapiens (Human)

PRO ID PR:Q86UL8
DAG View
PRO Name membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (human)
Definition A membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 that is encoded in the genome of human.
Short Label hMAGI2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86UL8 (MAGI2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y362 Phosphorylation PhosphoSitePlus
Y365 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
Y547 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
T675 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
S1001 Phosphorylation PhosphoSitePlus
T1003 Phosphorylation PhosphoSitePlus
S1014 Phosphorylation PhosphoSitePlus
Y1106 Phosphorylation PhosphoSitePlus
S1160 Phosphorylation PhosphoSitePlus
Y1172 Phosphorylation PhosphoSitePlus
T1206 Phosphorylation PhosphoSitePlus
K1215 Methylation PhosphoSitePlus
S1397 Phosphorylation PhosphoSitePlus
K1426 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1001 Phosphorylation HPRD 20068231
T1003 Phosphorylation HPRD 20068231
Y1172 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P60484 (PTEN) T383 Q86UL8 (MAGI2) unknown eFIP 11431330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y362 C362 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y365 * Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
Y365 C365 Biomuta DOID:1324 / lung cancer [ tcga ]
Y547 N547 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1160 G1160 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1160 N1160 Biomuta DOID:363 / uterine cancer [ tcga ]
K1426 E1426 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]