iPTMnet Report for Q86UL8 (MAGI2)
Protein Information
| UniProt AC / UniProt ID | Q86UL8 / MAGI2_HUMAN |
| Protein Name | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 |
| Gene Name | Name: MAGI2 Synonyms:ACVRINP1,AIP1,KIAA0705; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q86UL8 |
| PRO Name | membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (human) |
| Definition | A membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 that is encoded in the genome of human. |
| Short Label | hMAGI2 |
| Category | organism-gene |
DAG ViewQ86UL8 (MAGI2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y362 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y365 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y366 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y547 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S622 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T675 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S676 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S727 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1001 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1003 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1014 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1106 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1160 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1172 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1206 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1215 | Methylation | score1 | PhosphoSitePlus | |||
| S1397 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1426 | Acetylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | P60484 (PTEN) | T383 | Q86UL8 (MAGI2) | unknown | eFIP | 11431330 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y365 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y365 | C365 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| Y547 | N547 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S1160 | G1160 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S1160 | N1160 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K1426 | E1426 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] |
