iPTMnet Report for Q86UE8 (TLK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86UE8 / TLK2_HUMAN
Protein Name Serine/threonine-protein kinase tousled-like 2
Gene Name Name: TLK2
Organism Homo sapiens (Human)

PRO ID PR:Q86UE8
DAG View
PRO Name serine/threonine-protein kinase tousled-like 2 (human)
Definition A serine/threonine-protein kinase tousled-like 2 that is encoded in the genome of human.
Short Label hTLK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86UE8 (TLK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus   UniProt 23186163
T78 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
T98 Phosphorylation PhosphoSitePlus
S99 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 18669648, 23186163, ...19690332
S103 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S111 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S115 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S117 Phosphorylation PhosphoSitePlus   UniProt 23186163
S134 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
T140 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
T148 O-Glycosylation GlyGen 31492838, 34019948
K156 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
Y259 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus 21851590
S686 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
T695 Phosphorylation PhosphoSitePlus
S750 Phosphorylation neXtProt   UniProt 12955071
S750 Phosphorylation O14757 (CHEK1) neXtProt 12955071
S753 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation HPRD 18452278
S99 Phosphorylation HPRD 19413330, 18691976, 18669648, ...15302935
S110 Phosphorylation HPRD 18691976
S111 Phosphorylation HPRD 18669648
S115 Phosphorylation HPRD 19651622, 18669648
S731 Phosphorylation HPRD 18691976
S749 Phosphorylation HPRD 19413330, 18452278
Site PTM Type PTM Enzyme Score Source PMID
T78 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus


Q86UE8 (TLK2) as PTM Enzyme



Substrate Site Score Source PMID
Q9NVP2 (ASF1B) S198 neXtProt   PhosphoSitePlus   Signor 20016786
Q9Y294 (ASF1A) S192 neXtProt   PhosphoSitePlus   Signor 20016786, 11470414


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 C41 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T140 M140 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T140 A140 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T148 A148 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S182 N182 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K224 N224 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y259 F259 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K418 N418 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S617 L617 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S750 F750 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S761 A761 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
S770 Y770 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]