iPTMnet Report for Q86UE4 (MTDH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86UE4 / LYRIC_HUMAN
Protein Name Protein LYRIC
Gene Name Name: MTDH
Synonyms:AEG1,LYRIC;
Organism Homo sapiens (Human)

PRO ID PR:Q86UE4
DAG View
PRO Name protein LYRIC (human)
Definition A protein LYRIC that is encoded in the genome of human.
Short Label hMTDH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86UE4 (MTDH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S84 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
K88 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S111 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
K121 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
T143 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20166139, 18669648, 23186163, ...20068231
S146 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T148 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
K174 Acetylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus   UniProt 23186163
K185 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
S216 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 24275569
S219 Phosphorylation HPRD 20068231
K248 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus   UniProt 24275569
S258 Phosphorylation PhosphoSitePlus
K261 Methylation PhosphoSitePlus
K264 Methylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
T268 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
T280 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S294 Phosphorylation HPRD   PhosphoSitePlus 20166139
S295 Phosphorylation HPRD   PhosphoSitePlus 18767875
S298 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 21406692, 23186163, ...17081983, 18767875, 18578522, 19651622, 18669648, 25849741, 24275569, 20166139, 18088087, 20068231
K303 Ubiquitination PhosphoSitePlus
S306 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 20068230
S308 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...19664994, 19651622, 18669648, 24275569, 20068231, 20068230
S311 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 19651622, ...18669648, 20068231
K314 Acetylation PhosphoSitePlus
K314 Methylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus   UniProt 23186163
K334 Ubiquitination PhosphoSitePlus
R338 Methylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus   UniProt 23186163
S341 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus   UniProt 19690332
S347 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
T361 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus   UniProt 19690332
S411 Phosphorylation PhosphoSitePlus
S415 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983
S426 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 18578522, ...18088087, 17081983, 23186163, 18767875, 21406692, 18452278, 19651622, 18510355, 18669648, 24275569, 18707149, 20166139, 17287340, 20068231
T439 Phosphorylation HPRD   PhosphoSitePlus 18452278
K441 Acetylation PhosphoSitePlus
S457 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648
T458 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648
T462 Phosphorylation PhosphoSitePlus
S478 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 17081983
K491 Methylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
T492 O-Glycosylation GlyGen 30444036, 35132862, 28657654, ...35254053, 34019948, 32119511, 35289036, 22121020, 31373491
T492 Phosphorylation HPRD   PhosphoSitePlus 20068231
S494 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18578522, 23186163, 20068231
T495 O-Glycosylation GlyGen 30444036, 35132862, 28657654, ...35254053, 34019948, 32119511, 35289036, 22121020, 31373491
T495 Phosphorylation HPRD   PhosphoSitePlus 20068231
S496 O-Glycosylation GlyGen 30444036, 35132862, 28657654, ...35254053, 34019948, 32119511, 35289036, 22121020, 31373491
S496 Phosphorylation PhosphoSitePlus   UniProt 23186163
S506 Phosphorylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
T511 O-Glycosylation GlyGen 30444036, 35132862, 28657654, ...35254053, 34019948, 32119511, 35289036, 22121020, 31373491
T511 Phosphorylation PhosphoSitePlus
T516 O-Glycosylation GlyGen 30444036, 35132862, 28657654, ...35254053, 34019948, 32119511, 35289036, 22121020, 31373491
S521 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
T550 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
T560 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
T564 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S568 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 35494241, 23186163, 24708550, ...19651622, 18669648, 20068231
K570 Ubiquitination PhosphoSitePlus
T582 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T148 K148 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K150 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S180 A180 Biomuta DOID:1324 / lung cancer [ cosmic ]
S180 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S214 C214 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S219 L219 Biomuta DOID:4159 / skin cancer [ cosmic ]
S251 Y251 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S267 F267 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S267 Y267 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T280 S280 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K289 N289 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S306 F306 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S357 Y357 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S411 P411 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S411 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S426 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T439 I439 Biomuta DOID:363 / uterine cancer [ icgc ]
S457 C457 Biomuta DOID:1324 / lung cancer [ cosmic ]
T495 A495 Biomuta DOID:1324 / lung cancer [ cosmic ]
S496 N496 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S506 N506 Biomuta [ cosmic ]
K510 N510 Biomuta DOID:1324 / lung cancer [ cosmic ]
S521 F521 Biomuta DOID:4159 / skin cancer [ cosmic ]
S521 Y521 Biomuta DOID:1319 / brain cancer [ icgc ]
S529 P529 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S532 I532 Biomuta DOID:363 / uterine cancer [ icgc ]
S534 F534 Biomuta DOID:4159 / skin cancer [ cosmic ]
T550 I550 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T550 S550 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S558 A558 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S568 F568 Biomuta DOID:1319 / brain cancer [ cosmic ]