iPTMnet Report for Q86UB9 (TMEM135)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86UB9 / TM135_HUMAN
Protein Name Transmembrane protein 135
Gene Name Name: TMEM135
Organism Homo sapiens (Human)

PRO ID PR:Q86UB9
DAG View
PRO Name transmembrane protein 135 (human)
Definition A transmembrane protein 135 that is encoded in the genome of human.
Short Label hTMEM135
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86UB9 (TMEM135) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C12 Methylation IEDB 31844290
S110 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
S181 O-Glycosylation GlyGen 30620550
K189 Ubiquitination PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
C250 Methylation IEDB 31844290
Y344 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
T348 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y128 F128 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y128 H128 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S181 C181 Biomuta DOID:1612 / breast cancer [ icgc ]
Y344 H344 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]