Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86U86 / PB1_HUMAN
Protein Name Protein polybromo-1
Gene Name Name: PBRM1
Synonyms:BAF180,PB1;
Organism Homo sapiens (Human)

PRO ID PR:Q86U86
DAG View
PRO Name protein polybromo-1 (human)
Definition A protein polybromo-1 that is encoded in the genome of human.
Short Label hPBRM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86U86 (PBRM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
T9 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S10 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18220336
S12 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S25 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus 18669648, 18847512
S27 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T28 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus 18669648, 18847512
S32 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S39 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18669648, 24275569, ...19690332, 20068231
T43 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
T56 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
S131 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y134 Phosphorylation PhosphoSitePlus   UniProt 23186163
K154 Sumoylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
S178 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K214 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
S314 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S316 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K317 Ubiquitination PhosphoSitePlus
S319 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T327 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
K329 Methylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S353 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...19690332
S355 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...19690332
Y366 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus   UniProt 19690332
S375 Phosphorylation PhosphoSitePlus   UniProt 19690332
T377 Phosphorylation PhosphoSitePlus
K414 Acetylation PhosphoSitePlus
K415 Acetylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S501 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
T507 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus   UniProt 23186163
K569 Acetylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
S636 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 19690332, 20068231
S642 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus   UniProt 21406692
T656 Phosphorylation PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
Y672 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
S689 Phosphorylation PhosphoSitePlus   UniProt 23186163
K708 Ubiquitination PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
K930 Ubiquitination PhosphoSitePlus
S934 Phosphorylation PhosphoSitePlus
S948 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 15302935, ...24275569, 25066234
S987 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1019 Ubiquitination PhosphoSitePlus
K1025 Ubiquitination PhosphoSitePlus
K1030 Ubiquitination PhosphoSitePlus
S1069 Phosphorylation PhosphoSitePlus
K1074 Ubiquitination PhosphoSitePlus
S1099 Phosphorylation PhosphoSitePlus
S1116 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1167 Ubiquitination PhosphoSitePlus
S1168 Phosphorylation PhosphoSitePlus
K1181 Ubiquitination PhosphoSitePlus
K1213 Ubiquitination PhosphoSitePlus
S1278 Phosphorylation PhosphoSitePlus
S1280 Phosphorylation PhosphoSitePlus
K1293 Sumoylation PhosphoSitePlus
K1293 Ubiquitination PhosphoSitePlus
K1299 Ubiquitination PhosphoSitePlus
K1307 Ubiquitination PhosphoSitePlus
K1308 Ubiquitination PhosphoSitePlus
T1359 Phosphorylation PhosphoSitePlus
S1367 Phosphorylation PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
K1398 Sumoylation PhosphoSitePlus
K1398 Ubiquitination PhosphoSitePlus
Y1404 Phosphorylation PhosphoSitePlus
S1405 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1410 Phosphorylation PhosphoSitePlus
T1422 Phosphorylation PhosphoSitePlus
K1424 Ubiquitination PhosphoSitePlus
S1451 Phosphorylation PhosphoSitePlus
S1453 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16964243, 20068231
K1612 Ubiquitination PhosphoSitePlus
K1626 Ubiquitination PhosphoSitePlus
K1642 Ubiquitination PhosphoSitePlus
K1654 Methylation PhosphoSitePlus
K1654 Ubiquitination PhosphoSitePlus
K1656 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation HPRD 18669648, 17081983, 20068231
S10 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S12 Phosphorylation HPRD 17081983, 20068231
S14 Phosphorylation HPRD 17081983
S16 Phosphorylation HPRD 17081983, 18452278
S25 Phosphorylation HPRD 18669648, 20068231, 18452278
T28 Phosphorylation HPRD 18669648
S39 Phosphorylation HPRD 18669648, 20058876, 17081983, ...20068231
Y54 Phosphorylation HPRD 16094384
S131 Phosphorylation HPRD 18669648
S178 Phosphorylation HPRD 19413330, 18669648, 19691289, ...20068231, 18452278
T301 Phosphorylation HPRD 20068231, 17924679
S303 Phosphorylation HPRD 20068231
S314 Phosphorylation HPRD 18669648
S316 Phosphorylation HPRD 18669648
S319 Phosphorylation HPRD 18669648
S343 Phosphorylation HPRD 17081983
T346 Phosphorylation HPRD 17081983
Y351 Phosphorylation HPRD 17081983
S353 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S355 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
Y366 Phosphorylation HPRD 18452278
S371 Phosphorylation HPRD 20068231, 18452278
S375 Phosphorylation HPRD 20068231, 18452278
T377 Phosphorylation HPRD 18452278
S498 Phosphorylation HPRD 18452278
T507 Phosphorylation HPRD 20068231
S509 Phosphorylation HPRD 20068231
S636 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
S645 Phosphorylation HPRD 20068231
S648 Phosphorylation HPRD 20068231
S689 Phosphorylation HPRD 18452278
S948 Phosphorylation HPRD 18077418, 15302935
K990 Ubiquitination PhosphoSitePlus
S1143 Phosphorylation HPRD 20068231
S1353 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation HPRD 18669648, 17081983, 20068231
S10 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S12 Phosphorylation HPRD 17081983, 20068231
S14 Phosphorylation HPRD 17081983
S16 Phosphorylation HPRD 17081983, 18452278
S25 Phosphorylation HPRD 18669648, 20068231, 18452278
T28 Phosphorylation HPRD 18669648
S39 Phosphorylation HPRD 18669648, 20058876, 17081983, ...20068231
Y54 Phosphorylation HPRD 16094384
S131 Phosphorylation HPRD 18669648
S178 Phosphorylation HPRD 19413330, 18669648, 19691289, ...20068231, 18452278
T301 Phosphorylation HPRD 20068231, 17924679
S303 Phosphorylation HPRD 20068231
S314 Phosphorylation HPRD 18669648
S316 Phosphorylation HPRD 18669648
S319 Phosphorylation HPRD 18669648
S343 Phosphorylation HPRD 17081983
T346 Phosphorylation HPRD 17081983
Y351 Phosphorylation HPRD 17081983
S353 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S355 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
Y366 Phosphorylation HPRD 18452278
S371 Phosphorylation HPRD 20068231, 18452278
S375 Phosphorylation HPRD 20068231, 18452278
T377 Phosphorylation HPRD 18452278
S498 Phosphorylation HPRD 18452278
T507 Phosphorylation HPRD 20068231
S509 Phosphorylation HPRD 20068231
S636 Phosphorylation HPRD 19413330, 18691976, 18669648, ...20068231
S645 Phosphorylation HPRD 20068231
S648 Phosphorylation HPRD 20068231
S689 Phosphorylation HPRD 18452278
S948 Phosphorylation HPRD 18077418, 15302935
S1168 Phosphorylation HPRD 20068231
S1405 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T507 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
T516 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K990 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 T10 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S32 R32 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y54 C54 Biomuta DOID:2531 / hematologic cancer [ tcga ]
K96 * Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S131 Y131 Biomuta DOID:3571 / liver cancer [ icgc ]
K214 * Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
K231 R231 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
K250 R250 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S314 P314 Biomuta DOID:3571 / liver cancer [ tcga ]
S328 R328 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S343 L343 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S353 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S371 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K414 N414 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K415 * Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S502 * Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
S505 F505 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K623 R623 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S636 P636 Biomuta DOID:263 / kidney cancer [ cosmic ]
S648 Y648 Biomuta DOID:363 / uterine cancer [ tcga ]
S689 F689 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K930 N930 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1069 Y1069 Biomuta DOID:363 / uterine cancer [ tcga ]
S1116 * Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S1367 F1367 Biomuta DOID:363 / uterine cancer [ tcga ]
K1626 M1626 Biomuta DOID:3070 / malignant glioma [ tcga ]