iPTMnet Report for Q86TU7 (SETD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86TU7 / SETD3_HUMAN
Protein Name Actin-histidine N-methyltransferase
Gene Name Name: SETD3
Synonyms:C14orf154;
Organism Homo sapiens (Human)

PRO ID PR:Q86TU7
DAG View
PRO Name actin-histidine N-methyltransferase (human)
Definition An actin-histidine N-methyltransferase that is encoded in the genome of human.
Short Label hSETD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86TU7 (SETD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
S12 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T14 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T17 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
S21 Phosphorylation PhosphoSitePlus
K23 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
Y350 Phosphorylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S513 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S517 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 18669648
T14 Phosphorylation HPRD 18669648
T17 Phosphorylation HPRD 16094384
S513 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation HPRD 18669648
T14 Phosphorylation HPRD 18669648
T17 Phosphorylation HPRD 16094384


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K11 T11 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T14 I14 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S21 P21 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K35 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K74 N74 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
K466 Q466 Biomuta DOID:1319 / brain cancer [ cosmic ]
S517 L517 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]