Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86TI0 / TBCD1_HUMAN
Protein Name TBC1 domain family member 1
Gene Name Name: TBC1D1
Synonyms:KIAA1108;
Organism Homo sapiens (Human)

PRO ID PR:Q86TI0
DAG View
PRO Name TBC1 domain family member 1 (human)
Definition A TBC1 domain family member 1 that is encoded in the genome of human.
Short Label hTBC1D1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86TI0 (TBC1D1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation PhosphoSitePlus
Y90 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S235 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 17995453, 24879834
S237 Phosphorylation Q13131 (PRKAA1) , P54646 (PRKAA2) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30135087, 20837646, 25280670, ...24247980, 24275569, 17995453
K248 Ubiquitination PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
K497 Acetylation PhosphoSitePlus
K501 Acetylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus   UniProt 19690332
S513 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus   UniProt 19690332
S566 Phosphorylation PhosphoSitePlus
S570 Phosphorylation PhosphoSitePlus   UniProt 19690332
S571 Phosphorylation PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus   UniProt 19690332, 24275569
T596 Phosphorylation P31749 (AKT1) , Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 24879834, 25280670, 24247980, ...17995453, 22851577
S598 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
T652 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
Y880 Phosphorylation PhosphoSitePlus
K1092 Ubiquitination PhosphoSitePlus
S1137 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y113 Phosphorylation HPRD 15592455
Site PTM Type PTM Enzyme Score Source PMID
S667 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049403 (hTBC1D1/Phos:1) pS237 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S237 P237 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T410 A410 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K501 E501 Biomuta DOID:363 / uterine cancer [ tcga ]
S503 Y503 Biomuta DOID:363 / uterine cancer [ tcga ]
S513 F513 Biomuta DOID:10534 / stomach cancer [ icgc ]
S527 N527 Biomuta DOID:1324 / lung cancer [ tcga ]
S570 F570 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S585 L585 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S618 L618 Biomuta DOID:0070003 / blastoma [ cosmic ]
S660 F660 Biomuta DOID:363 / uterine cancer [ tcga ]
Y880 C880 Biomuta DOID:363 / uterine cancer [ tcga ]
S1137 L1137 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]