iPTMnet Report for Q86T82 (USP37)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86T82 / UBP37_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 37
Gene Name Name: USP37
Synonyms:KIAA1594;
Organism Homo sapiens (Human)

PRO ID PR:Q86T82
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 37 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 37 that is encoded in the genome of human.
Short Label hUSP37
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86T82 (USP37) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   UniProt 34606619
S138 Phosphorylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
R168 Methylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus   UniProt 23186163
T191 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus   UniProt 23186163
T211 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
R288 Methylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
T417 Phosphorylation PhosphoSitePlus
K446 Acetylation PhosphoSitePlus
K452 Sumoylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
C473 Methylation IEDB 31844290
K498 Ubiquitination PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
T627 Phosphorylation PhosphoSitePlus
S628 Phosphorylation P24941 (CDK2) neXtProt   PhosphoSitePlus   Signor   UniProt 21596315, 27296872
T631 Phosphorylation PhosphoSitePlus
S650 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S652 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K681 Ubiquitination PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
S770 Phosphorylation PhosphoSitePlus   UniProt 23186163
K776 Ubiquitination PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
K916 Ubiquitination PhosphoSitePlus
K962 Ubiquitination PhosphoSitePlus
K973 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S650 Phosphorylation HPRD 19413330, 18669648, 17081983
S652 Phosphorylation HPRD 18669648, 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 Y2 Biomuta DOID:363 / uterine cancer [ icgc ]
S138 P138 Biomuta DOID:263 / kidney cancer [ cosmic ]
S138 C138 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S170 L170 Biomuta DOID:363 / uterine cancer [ icgc ]
S227 L227 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S268 F268 Biomuta DOID:4159 / skin cancer [ cosmic ]
R288 S288 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S312 F312 Biomuta [ cosmic ]
C473 S473 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S573 T573 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S573 L573 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T627 I627 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K681 N681 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S698 L698 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K962 N962 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]