iPTMnet Report for Q86SQ0 (PHLDB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q86SQ0 / PHLB2_HUMAN
Protein Name Pleckstrin homology-like domain family B member 2
Gene Name Name: PHLDB2
Synonyms:LL5B;
Organism Homo sapiens (Human)

PRO ID PR:Q86SQ0
DAG View
PRO Name pleckstrin homology-like domain family B member 2 (human)
Definition A pleckstrin homology-like domain family B member 2 that is encoded in the genome of human.
Short Label hPHLDB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q86SQ0 (PHLDB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K50 Methylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
S71 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S73 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S81 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
S157 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 19690332
Y162 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S163 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
S204 Phosphorylation IEDB   PhosphoSitePlus 31848261
K206 Acetylation PhosphoSitePlus
S212 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S216 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K240 Methylation PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S244 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S245 Phosphorylation PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
T268 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
T284 Phosphorylation PhosphoSitePlus
K285 Acetylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S308 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S309 Phosphorylation phospho.ELM 18669648
Y324 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S334 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S347 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S348 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S351 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S384 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S387 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T404 Phosphorylation phospho.ELM   PhosphoSitePlus 16964243
S414 Phosphorylation phospho.ELM 18669648
S415 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S417 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S418 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus   UniProt 24275569
S455 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S468 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T469 Phosphorylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
S489 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 20068231
S493 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S501 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T504 Phosphorylation PhosphoSitePlus   UniProt 20068231
S513 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S521 Phosphorylation phospho.ELM 18669648
S524 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S526 Phosphorylation phospho.ELM 18669648
S528 Phosphorylation PhosphoSitePlus
T534 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
T550 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S556 O-Glycosylation GlyGen 31373491
T557 O-Glycosylation GlyGen 30379171, 31373491
T557 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
S565 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S566 Phosphorylation PhosphoSitePlus
Y567 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
T574 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S635 O-Glycosylation GlyGen 30379171
K659 Ubiquitination PhosphoSitePlus
K665 Acetylation PhosphoSitePlus
T666 Phosphorylation PhosphoSitePlus
K667 Acetylation PhosphoSitePlus
Y686 Phosphorylation PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
K810 Ubiquitination PhosphoSitePlus
Y811 Phosphorylation PhosphoSitePlus
S812 Phosphorylation PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
K818 Ubiquitination PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
Y894 Phosphorylation PhosphoSitePlus
S896 Phosphorylation PhosphoSitePlus
T898 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S907 Phosphorylation PhosphoSitePlus
S909 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S914 Phosphorylation PhosphoSitePlus
T916 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
S934 Phosphorylation PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus
S942 Phosphorylation PhosphoSitePlus
S980 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
S988 Phosphorylation PhosphoSitePlus
S995 Phosphorylation IEDB 32157095
K1063 Acetylation PhosphoSitePlus
K1090 Ubiquitination PhosphoSitePlus
T1110 Phosphorylation PhosphoSitePlus
T1128 Phosphorylation PhosphoSitePlus
K1156 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S71 Phosphorylation HPRD 18669648, 20068231
S73 Phosphorylation HPRD 18669648, 19691289, 20068231
Y131 Phosphorylation HPRD 17016520
S157 Phosphorylation HPRD 19651622, 18669648, 18212344
Y162 Phosphorylation HPRD 18669648
S212 Phosphorylation HPRD 18669648
Y241 Phosphorylation HPRD 18491316
S242 Phosphorylation HPRD 18491316
S243 Phosphorylation HPRD 18491316
S244 Phosphorylation HPRD 18491316
S245 Phosphorylation HPRD 18491316
Y252 Phosphorylation HPRD 18491316
S308 Phosphorylation HPRD 18669648, 20068231
S309 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648, 18491316, 19664995, ...19691289
S347 Phosphorylation HPRD 18669648
S348 Phosphorylation HPRD 18669648
S351 Phosphorylation HPRD 18669648
S384 Phosphorylation HPRD 18669648
S387 Phosphorylation HPRD 18669648
T404 Phosphorylation HPRD 16964243, 19691289
S414 Phosphorylation HPRD 18669648
S415 Phosphorylation HPRD 20166139, 18669648
S417 Phosphorylation HPRD 18669648
S465 Phosphorylation HPRD 20068231
S468 Phosphorylation HPRD 18691976, 19691289, 18452278, ...18669648, 19007248, 20068231
S489 Phosphorylation HPRD 18491316, 15302935, 18452278, ...18669648, 20166139, 20068231
S493 Phosphorylation HPRD 20166139, 18669648, 18452278
S501 Phosphorylation HPRD 18669648, 20068231, 18452278
T504 Phosphorylation HPRD 20068231
S513 Phosphorylation HPRD 18669648
S521 Phosphorylation HPRD 18669648
S524 Phosphorylation HPRD 18669648
S526 Phosphorylation HPRD 18669648
T550 Phosphorylation HPRD 18669648
S565 Phosphorylation HPRD 18669648
T574 Phosphorylation HPRD 18669648, 19691289
T855 Phosphorylation HPRD 18669648, 19664994
S866 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S58 F58 Biomuta DOID:4159 / skin cancer [ cosmic ]
S71 I71 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S73 F73 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S81 C81 Biomuta DOID:363 / uterine cancer [ icgc ]
Y148 C148 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S149 C149 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S157 L157 Biomuta DOID:4159 / skin cancer [ cosmic ]
S196 P196 Biomuta DOID:1324 / lung cancer [ cosmic ]
S196 L196 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S212 N212 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S243 I243 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S277 Y277 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S277 C277 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S294 R294 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y301 C301 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y301 H301 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S306 Y306 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S347 F347 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ]
S415 G415 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S501 I501 Biomuta DOID:1324 / lung cancer [ cosmic ]
S501 N501 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S513 Y513 Biomuta DOID:363 / uterine cancer [ icgc ]
S521 G521 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T557 P557 Biomuta DOID:1612 / breast cancer [ cosmic ]
S563 N563 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S569 I569 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S569 N569 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K659 N659 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T666 I666 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y811 C811 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S812 C812 Biomuta DOID:1324 / lung cancer [ cosmic ]
S812 Y812 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K818 * Biomuta [ cosmic ]
S881 G881 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S881 N881 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y894 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y894 H894 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S982 * Biomuta DOID:184 / bone cancer [ cosmic ]
S995 C995 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic, icgc, cosmic, cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ icgc, cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc, cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1156 * Biomuta DOID:4159 / skin cancer [ cosmic ]