iPTMnet Report for Q7Z7M0 (MEGF8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z7M0 / MEGF8_HUMAN
Protein Name Multiple epidermal growth factor-like domains protein 8 precursor
Gene Name Name: MEGF8
Synonyms:C19orf49,EGFL4,KIAA0817;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z7M0
DAG View
PRO Name multiple epidermal growth factor-like domains protein 8 (human)
Definition A multiple epidermal growth factor-like domains protein 8 that is encoded in the genome of human.
Short Label hMEGF8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z7M0 (MEGF8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
N134 N-Glycosylation GlyGen 29391424
S140 Phosphorylation PhosphoSitePlus
N217 N-Glycosylation GlyGen 23090970, 24190977
N421 N-Glycosylation GlyGen 23090970, 29671580, 29391424, ...24190977
N637 N-Glycosylation GlyGen 23090970, 24190977
N1048 N-Glycosylation GlyGen 24190977
N1115 N-Glycosylation GlyGen 23090970, 24190977
T1149 O-Glycosylation GlyGen 30459171
S1169 Phosphorylation PhosphoSitePlus
S1198 Phosphorylation PhosphoSitePlus
N1201 N-Glycosylation GlyGen 23090970, 29391424, 24190977
Y1250 Phosphorylation PhosphoSitePlus
S1258 Phosphorylation PhosphoSitePlus
N1271 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29391424, ...24190977
S1543 Phosphorylation PhosphoSitePlus
N1600 N-Glycosylation GlyGen 29391424
S1749 Phosphorylation PhosphoSitePlus
S1790 Phosphorylation PhosphoSitePlus
T1796 Phosphorylation PhosphoSitePlus
N1887 N-Glycosylation GlyGen 24190977
T1951 Phosphorylation PhosphoSitePlus
R2023 Methylation PhosphoSitePlus
T2031 Phosphorylation IEDB 32387766
S2280 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N421 N-Glycosylation PRO 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N1115 D1115 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
N1201 D1201 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1250 C1250 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T1951 A1951 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R2023 H2023 Biomuta DOID:1319 / brain cancer [ cosmic ]
R2023 C2023 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]