iPTMnet Report for Q7Z7H5 (TMED4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z7H5 / TMED4_HUMAN
Protein Name Transmembrane emp24 domain-containing protein 4 precursor
Gene Name Name: TMED4
Synonyms:ERS25;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z7H5
DAG View
PRO Name transmembrane emp24 domain-containing protein 4 (human)
Definition A transmembrane emp24 domain-containing protein 4 that is encoded in the genome of human.
Short Label hTMED4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z7H5 (TMED4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C41 Methylation IEDB 31844290
K63 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
N117 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
K128 Ubiquitination PhosphoSitePlus
K152 Acetylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
K172 Acetylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
K218 Acetylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K65 N65 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K65 Q65 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S71 L71 Biomuta DOID:1324 / lung cancer [ cosmic ]
S91 F91 Biomuta DOID:4159 / skin cancer [ cosmic ]
K128 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K152 M152 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K224 N224 Biomuta DOID:363 / uterine cancer [ icgc ]