iPTMnet Report for Q7Z739 (YTHDF3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z739 / YTHD3_HUMAN
Protein Name YTH domain-containing family protein 3
Gene Name Name: YTHDF3
Organism Homo sapiens (Human)

PRO ID PR:Q7Z739
DAG View
PRO Name YTH domain-containing family protein 3 (human)
Definition A YTH domain-containing family protein 3 that is encoded in the genome of human.
Short Label hYTHDF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z739 (YTHDF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22814378
S2 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
N21 N-Glycosylation GlyGen 29741879
S23 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
T115 Phosphorylation IEDB 32387766
S149 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
Y151 Phosphorylation PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
S160 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
S161 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
T167 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
N175 N-Glycosylation GlyGen 29741879
T177 Phosphorylation PhosphoSitePlus
T201 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
T201 Phosphorylation HPRD 20068231
T205 O-Glycosylation GlyGen   PhosphoSitePlus 29249144, 35138101, 30620550, ...31492838, 35289036, 29351928, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 28657654, 34846842, 33214551, 30379171, 30059200, 35254053, 34019948, 36240223, 20068230
T205 Phosphorylation PhosphoSitePlus
T207 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
T210 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
S213 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
S214 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
T222 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
S224 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
S229 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
S230 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
T236 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
K244 Ubiquitination PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
S383 O-Glycosylation GlyGen 35138101, 30620550, 31492838, ...35289036, 35254053, 22661428, 29237092, 27114449, 31373491, 32119511, 32574038, 35132862, 20305658, 29351928, 28657654, 34846842, 33214551, 30379171, 30059200, 29249144, 34019948, 36240223, 20068230
S383 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S385 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
K397 Ubiquitination PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
Y452 Phosphorylation PhosphoSitePlus
R520 Methylation PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 L23 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S149 F149 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S160 G160 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S229 N229 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S425 A425 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S436 C436 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R520 H520 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]