Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z6J4 / FGD2_HUMAN
Protein Name FYVE, RhoGEF and PH domain-containing protein 2
Gene Name Name: FGD2
Synonyms:ZFYVE4;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z6J4
DAG View
PRO Name FYVE, RhoGEF and PH domain-containing protein 2 (human)
Definition A FYVE, RhoGEF and PH domain-containing protein 2 that is encoded in the genome of human.
Short Label hFGD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z6J4 (FGD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
T67 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
Y350 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus   UniProt 24275569


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T67 P67 Biomuta DOID:1612 / breast cancer [ icgc ]
T67 R67 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S549 G549 Biomuta DOID:1612 / breast cancer [ tcga ]
S561 I561 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]