iPTMnet Report for Q7Z699 (SPRED1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z699 / SPRE1_HUMAN
Protein Name Sprouty-related, EVH1 domain-containing protein 1
Gene Name Name: SPRED1
Organism Homo sapiens (Human)

PRO ID PR:Q7Z699
DAG View
PRO Name sprouty-related, EVH1 domain-containing protein 1 (human)
Definition A sprouty-related, EVH1 domain-containing protein 1 that is encoded in the genome of human.
Short Label hSPRED1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z699 (SPRED1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
S2 Phosphorylation PhosphoSitePlus
T5 Phosphorylation HPRD   PhosphoSitePlus 20230923
T7 Phosphorylation HPRD 20230923
S8 Phosphorylation HPRD 20230923
Y82 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus   RLIMS-P 32697994
S124 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
S222 O-Glycosylation GlyGen 30379171
K224 Methylation PhosphoSitePlus   UniProt 24129315
K232 Methylation PhosphoSitePlus
S238 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18578522, 23186163
K284 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
Y294 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus   UniProt 23186163
K312 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q7Z699 (SPRED1) S105 P21359 (NF1) inhibited_association eFIP 32697994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S124 F124 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K224 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S238 I238 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
Y292 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y292 C292 Biomuta DOID:1612 / breast cancer [ icgc ]
Y292 F292 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S308 F308 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S308 Y308 Biomuta DOID:363 / uterine cancer [ icgc ]
K312 R312 Biomuta DOID:4159 / skin cancer [ cosmic ]