iPTMnet Report for Q7Z698 (SPRED2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z698 / SPRE2_HUMAN
Protein Name Sprouty-related, EVH1 domain-containing protein 2
Gene Name Name: SPRED2
Organism Homo sapiens (Human)

PRO ID PR:Q7Z698
DAG View
PRO Name sprouty-related, EVH1 domain-containing protein 2 (human)
Definition A sprouty-related, EVH1 domain-containing protein 2 that is encoded in the genome of human.
Short Label hSPRED2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z698 (SPRED2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S104 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
Y192 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y228 Phosphorylation IntAct   PhosphoSitePlus   UniProt 17094949
Y231 Phosphorylation IntAct   PhosphoSitePlus   UniProt 17094949
K239 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S206 Phosphorylation HPRD 18578522


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y192 C192 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y251 F251 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y264 C264 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y266 C266 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y268 S268 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S286 N286 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S297 L297 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ]