Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z5L9 / I2BP2_HUMAN
Protein Name Interferon regulatory factor 2-binding protein 2
Gene Name Name: IRF2BP2
Organism Homo sapiens (Human)

PRO ID PR:Q7Z5L9
DAG View
PRO Name interferon regulatory factor 2-binding protein 2 (human)
Definition An interferon regulatory factor 2-binding protein 2 that is encoded in the genome of human.
Short Label hIRF2BP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z5L9 (IRF2BP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S15 Phosphorylation PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus   UniProt 24275569
S78 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
R109 Methylation PhosphoSitePlus
R116 Methylation PhosphoSitePlus
R125 Methylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus   UniProt 20068231, 17081983, 24275569
T197 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
R291 Methylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus   UniProt 24275569
S323 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 21887377, ...25260593, 19690332, 20068231
S381 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
T404 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S457 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S460 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S462 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S175 Phosphorylation HPRD 17081983, 19651622, 18669648, ...20166139, 19415658, 20068231
S240 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 20166139, 20068231
S242 Phosphorylation HPRD 20166139
S272 Phosphorylation HPRD 18452278
S318 Phosphorylation HPRD 20166139
S323 Phosphorylation HPRD 20166139
S360 Phosphorylation HPRD 17081983, 20058876, 19664995, ...18452278, 19651622, 18669648, 18707149, 20166139, 20068231, 18212344
S381 Phosphorylation HPRD 20068231
S396 Phosphorylation HPRD 17081983
T404 Phosphorylation HPRD 20068231
S406 Phosphorylation HPRD 19651622, 20068231
T412 Phosphorylation HPRD 18452278
T413 Phosphorylation HPRD 18452278
S423 Phosphorylation HPRD 18452278
S455 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S457 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S460 Phosphorylation HPRD 19413330, 15302935, 19664995, ...19651622, 18669648, 20068231
S462 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
S463 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
S175 Phosphorylation HPRD 17081983, 19651622, 18669648, ...20166139, 19415658, 20068231
S240 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 20166139, 20068231
S242 Phosphorylation HPRD 20166139
S272 Phosphorylation HPRD 18452278
S318 Phosphorylation HPRD 20166139
S323 Phosphorylation HPRD 20166139
K327 Ubiquitination PhosphoSitePlus
S344 Phosphorylation HPRD 17081983, 20058876, 19664995, ...18452278, 19651622, 18669648, 18707149, 20166139, 20068231, 18212344
S365 Phosphorylation HPRD 20068231
S380 Phosphorylation HPRD 17081983
T388 Phosphorylation HPRD 20068231
S390 Phosphorylation HPRD 19651622, 20068231
T396 Phosphorylation HPRD 18452278
T397 Phosphorylation HPRD 18452278
S407 Phosphorylation HPRD 18452278
S439 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S441 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S444 Phosphorylation HPRD 19413330, 17081983, 19664995, ...19651622, 18669648, 20068231
S446 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
S447 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 D2 Biomuta DOID:3571 / liver cancer [ icgc ]
S78 P78 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S272 G272 Biomuta DOID:3571 / liver cancer [ icgc ]
S290 R290 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S318 * Biomuta DOID:1324 / lung cancer [ tcga ]
K327 N327 Biomuta DOID:10534 / stomach cancer [ tcga ]
S399 C399 Biomuta DOID:1612 / breast cancer [ cosmic ]
S455 G455 Biomuta DOID:3571 / liver cancer [ icgc ]
S457 T457 Biomuta DOID:1324 / lung cancer [ cosmic ]
K539 R539 Biomuta DOID:10534 / stomach cancer [ tcga ]