iPTMnet Report for Q7Z5K2 (WAPL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z5K2 / WAPL_HUMAN
Protein Name Wings apart-like protein homolog
Gene Name Name: WAPL
Synonyms:FOE,KIAA0261,WAPAL;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z5K2
DAG View
PRO Name wings apart-like protein homolog (human)
Definition A wings apart-like protein that is encoded in the genome of human.
Short Label hWAPL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z5K2 (WAPL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Acetylation PhosphoSitePlus
K19 Acetylation PhosphoSitePlus
K27 Acetylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
S77 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...19369195, 15302935, 22067460, 18669648, 24275569, 19690332, 20068231
S81 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K93 Ubiquitination PhosphoSitePlus
C94 S-Nitrosylation dbSNO 26338901
S98 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S130 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
K168 Acetylation PhosphoSitePlus   UniProt 19608861
S180 Phosphorylation PhosphoSitePlus
S190 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T191 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S202 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
S221 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...22067460, 18669648, 24275569, 20068231
S223 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S226 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 22067460, 27920218, 18669648, 20068231
S231 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S254 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S257 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S286 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T291 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K303 Ubiquitination PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
S347 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
T355 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
S380 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 23186163, ...19690332
T385 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
T388 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K408 Ubiquitination PhosphoSitePlus
S420 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T436 Phosphorylation PhosphoSitePlus
S443 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 23186163
S445 Phosphorylation PhosphoSitePlus
Y448 Phosphorylation PhosphoSitePlus
Y452 Phosphorylation PhosphoSitePlus
S459 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 17081983
S461 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 17081983
S487 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S498 Phosphorylation PhosphoSitePlus
S523 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K541 Methylation PhosphoSitePlus
S544 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S549 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T551 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
Y555 Phosphorylation PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
Y616 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
Y633 Phosphorylation PhosphoSitePlus
K763 Acetylation PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
K812 Ubiquitination PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K843 Ubiquitination PhosphoSitePlus
K886 Ubiquitination PhosphoSitePlus
S904 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648
K911 Ubiquitination PhosphoSitePlus
K1059 Ubiquitination PhosphoSitePlus
T1063 Phosphorylation PhosphoSitePlus
T1064 Phosphorylation PhosphoSitePlus
S1069 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T1075 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S1076 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K1107 Ubiquitination PhosphoSitePlus
S1153 Phosphorylation PhosphoSitePlus
K1178 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y9 Phosphorylation HPRD 17081983
S77 Phosphorylation HPRD 19413330, 18691976, 20058876, ...19664995, 18452278, 17322306, 18669648, 19415658, 20068231
S81 Phosphorylation HPRD 18669648, 20068231
S221 Phosphorylation HPRD 19413330, 18691976, 18212344, ...20230923, 18767875, 20058876, 19651622, 18452278, 17322306, 18669648, 18707149, 20166139, 19415658, 20068231
S223 Phosphorylation HPRD 19651622, 20166139, 18669648, ...17081983, 19415658
S226 Phosphorylation HPRD 18691976, 20230923, 18767875, ...18452278, 19651622, 17322306, 18669648, 19415658, 20068231
S231 Phosphorylation HPRD 20230923
S380 Phosphorylation HPRD 18669648, 19691289, 18452278
Y452 Phosphorylation HPRD 17081983
S459 Phosphorylation HPRD 18669648, 17081983, 18452278
S461 Phosphorylation HPRD 18669648, 17081983, 18452278
T621 Phosphorylation HPRD 20068231
S904 Phosphorylation HPRD 18669648
S1153 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K27 N27 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S156 I156 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S158 I158 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S202 F202 Biomuta DOID:4159 / skin cancer [ icgc, tcga ]
S221 L221 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S226 P226 Biomuta DOID:3571 / liver cancer [ cosmic ]
S257 N257 Biomuta DOID:363 / uterine cancer [ icgc ]
S286 R286 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S347 I347 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S380 N380 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T385 A385 Biomuta DOID:1319 / brain cancer [ icgc ]
S420 F420 Biomuta DOID:4159 / skin cancer [ cosmic ]
S459 R459 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S487 C487 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S498 F498 Biomuta DOID:4159 / skin cancer [ cosmic ]
S498 Y498 Biomuta DOID:3571 / liver cancer [ cosmic ]
K829 E829 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S904 N904 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]