Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z589 / EMSY_HUMAN
Protein Name BRCA2-interacting transcriptional repressor EMSY
Gene Name Name: EMSY
Synonyms:C11orf30;ORFNames:GL002;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z589
DAG View
PRO Name BRCA2-interacting transcriptional repressor EMSY (human)
Definition A transcriptional repressor EMSY that is encoded in the genome of human.
Short Label hEMSY
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z589 (EMSY) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation PhosphoSitePlus
Y28 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S173 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S176 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28099152, 23186163, 19690332
S209 Phosphorylation P31749 (AKT1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 15302935, ...18669648, 28099152, 22315412, 20068231
S210 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S228 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23301498, 27114449, 27655845, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
K229 Ubiquitination PhosphoSitePlus
T230 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T232 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S236 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23301498, 27114449, 27655845, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S238 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S238 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15302935
S247 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S257 Phosphorylation PhosphoSitePlus
T262 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T262 Phosphorylation PhosphoSitePlus
T264 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S267 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T268 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T270 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T271 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23301498, 27114449, 27655845, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T273 Phosphorylation PhosphoSitePlus
T274 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T274 Phosphorylation PhosphoSitePlus
T282 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T283 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S284 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S286 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S287 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S287 Phosphorylation PhosphoSitePlus
T288 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S295 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
K296 Ubiquitination PhosphoSitePlus
Y300 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K451 Sumoylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
T476 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T501 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23301498, 27114449, 27655845, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T502 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T502 Phosphorylation PhosphoSitePlus
T504 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T504 Phosphorylation PhosphoSitePlus
T506 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23301498, 27114449, 27655845, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T509 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T511 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T511 Phosphorylation PhosphoSitePlus
T514 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S516 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S518 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T530 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
T534 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 27114449, 27655845, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T535 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 27114449, 27655845, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S536 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S538 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T541 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T541 Phosphorylation PhosphoSitePlus
S546 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S546 Phosphorylation PhosphoSitePlus
K553 Ubiquitination PhosphoSitePlus
S556 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S557 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S561 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T563 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T565 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T565 Phosphorylation PhosphoSitePlus
T568 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T568 Phosphorylation PhosphoSitePlus
T569 Phosphorylation PhosphoSitePlus
T573 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S574 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
K575 Ubiquitination PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
K620 Acetylation PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
K639 Sumoylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
K669 Ubiquitination PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
K710 Sumoylation PhosphoSitePlus
K710 Ubiquitination PhosphoSitePlus
Y762 Phosphorylation PhosphoSitePlus
K788 Ubiquitination PhosphoSitePlus
S793 Phosphorylation PhosphoSitePlus
T799 Phosphorylation PhosphoSitePlus
K815 Ubiquitination PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
T868 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S876 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S876 Phosphorylation PhosphoSitePlus
T880 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T882 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S883 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S893 Phosphorylation PhosphoSitePlus
S946 Phosphorylation PhosphoSitePlus
K950 Ubiquitination PhosphoSitePlus
K953 Ubiquitination PhosphoSitePlus
K967 Ubiquitination PhosphoSitePlus
K975 Ubiquitination PhosphoSitePlus
K977 Ubiquitination PhosphoSitePlus
K990 Ubiquitination PhosphoSitePlus
K1003 Ubiquitination PhosphoSitePlus
K1015 Sumoylation PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus
K1028 Ubiquitination PhosphoSitePlus
K1066 Ubiquitination PhosphoSitePlus
T1073 Phosphorylation PhosphoSitePlus
S1079 Phosphorylation PhosphoSitePlus
T1098 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T1115 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T1120 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23301498, 27114449, 27655845, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S1123 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
S1124 O-Glycosylation GlyGen 23301498, 27655845, 27114449, ...31637018, 30059200, 21740066, 29249144, 20305658, 21158410, 29351928, 28657654, 29237092, 20068230
T1129 Phosphorylation PhosphoSitePlus
S1130 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1134 Phosphorylation PhosphoSitePlus
S1136 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...18669648, 20068231
S1141 Phosphorylation PhosphoSitePlus
K1143 Ubiquitination PhosphoSitePlus
N1199 N-Glycosylation GlyGen 29741879
S1200 Phosphorylation PhosphoSitePlus
T1201 Phosphorylation PhosphoSitePlus
S1210 Phosphorylation PhosphoSitePlus
S1212 Phosphorylation PhosphoSitePlus
S1213 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
T1216 Phosphorylation PhosphoSitePlus
S1219 Phosphorylation PhosphoSitePlus
T1223 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation HPRD 20068231
T110 Phosphorylation HPRD 20068231
T115 Phosphorylation HPRD 20068231
T136 Phosphorylation HPRD 20068231
S168 Phosphorylation HPRD 20068231
S173 Phosphorylation HPRD 18669648, 20068231
S209 Phosphorylation HPRD 19413330, 15302935, 19664995, ...19691289, 18669648, 20068231
S213 Phosphorylation HPRD 19413330
S238 Phosphorylation HPRD 19413330, 15302935, 19664995, ...20068231, 19691289
T262 Phosphorylation HPRD 17924679
T273 Phosphorylation HPRD 17924679
T274 Phosphorylation HPRD 17924679
S518 Phosphorylation HPRD 20068231
T525 Phosphorylation HPRD 20068231
T530 Phosphorylation HPRD 20068231
Y531 Phosphorylation HPRD 20068231
T1129 Phosphorylation HPRD 18767875, 20068231
S1130 Phosphorylation HPRD 19413330, 18767875, 18669648, ...16964243, 20068231
S1136 Phosphorylation HPRD 19413330, 16964243, 15302935, ...19664995, 19691289, 18669648, 20068231
S1212 Phosphorylation HPRD 19691289, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y188 H188 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
S209 F209 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
S210 F210 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
S211 I211 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, tcga ]
S213 C213 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S267 L267 Biomuta DOID:1324 / lung cancer [ tcga ]
S267 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T274 A274 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
S466 I466 Biomuta DOID:3571 / liver cancer [ icgc ]
T509 P509 Biomuta DOID:1612 / breast cancer [ tcga ]
S516 R516 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K553 N553 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T563 M563 Biomuta DOID:1612 / breast cancer [ icgc ]
S574 F574 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K583 N583 Biomuta DOID:1324 / lung cancer [ tcga ]
K597 T597 Biomuta DOID:363 / uterine cancer [ tcga ]
S643 C643 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K655 E655 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K669 T669 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y762 H762 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
S823 L823 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S883 L883 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K950 * Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K977 Q977 Biomuta DOID:1324 / lung cancer [ cosmic ]
K990 R990 Biomuta DOID:3070 / malignant glioma [ cosmic ]
K1066 R1066 Biomuta DOID:363 / uterine cancer [ tcga ]
S1079 L1079 Biomuta DOID:1612 / breast cancer [ icgc ]
T1115 I1115 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1130 L1130 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T1201 A1201 Biomuta DOID:363 / uterine cancer [ tcga ]
S1212 L1212 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:363 / uterine cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]