iPTMnet Report for Q7Z4V5 (HDGFL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z4V5 / HDGR2_HUMAN
Protein Name Hepatoma-derived growth factor-related protein 2
Gene Name Name: HDGFL2
Synonyms:HDGF2;ORFNames:UNQ785/PRO1604;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z4V5
DAG View
PRO Name hepatoma-derived growth factor-related protein 2 (human)
Definition A hepatoma-derived growth factor-related protein 2 that is encoded in the genome of human.
Short Label hHDGFRP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z4V5 (HDGFL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K16 Ubiquitination PhosphoSitePlus
Y18 Phosphorylation PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   UniProt 24275569
S137 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
S142 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Methylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus   UniProt 23186163
K168 Methylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus   UniProt 18669648
S232 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S234 Phosphorylation PhosphoSitePlus   UniProt 18669648
S236 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
S253 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus   UniProt 24275569
S303 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus   UniProt 24275569
S366 Phosphorylation PhosphoSitePlus   UniProt 17081983
S369 Phosphorylation PhosphoSitePlus   UniProt 17081983
S370 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983
K383 Methylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus   UniProt 21406692
S396 Phosphorylation PhosphoSitePlus   UniProt 21406692
S397 Phosphorylation PhosphoSitePlus   UniProt 21406692
S399 Phosphorylation PhosphoSitePlus   UniProt 21406692
S412 Phosphorylation PhosphoSitePlus
S418 O-Glycosylation GlyGen 23301498, 30379171, 34019948, ...29351928
S454 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S458 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K494 Ubiquitination PhosphoSitePlus
C496 Methylation IEDB 31844290
K524 Acetylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K554 Acetylation PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
K560 Acetylation PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20068231
C631 S-Nitrosylation dbSNO 26338901
S633 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
S634 Phosphorylation PhosphoSitePlus   UniProt 21406692
S640 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S664 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 20068231
S671 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S137 Phosphorylation HPRD 19664994, 18212344, 18452278
S142 Phosphorylation HPRD 19651622
S144 Phosphorylation HPRD 19651622
S146 Phosphorylation HPRD 19651622
S149 Phosphorylation HPRD 19651622
S174 Phosphorylation HPRD 18452278
S175 Phosphorylation HPRD 18452278
T205 Phosphorylation HPRD 19651622
S230 Phosphorylation HPRD 19651622, 18669648, 20068231
S232 Phosphorylation HPRD 19651622, 18669648, 17287340, ...20068231
S234 Phosphorylation HPRD 19651622, 18669648, 17287340, ...20068231
S236 Phosphorylation HPRD 17287340, 20068231, 18452278
S240 Phosphorylation HPRD 17287340, 17081983, 18767875, ...18452278, 19651622, 18669648, 20068231
S366 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18669648, 20068231
S369 Phosphorylation HPRD 17287340, 17081983, 18767875, ...18452278, 19651622, 18669648, 20068231
S370 Phosphorylation HPRD 17287340, 17081983, 18767875, ...18452278, 19651622, 18669648, 20068231
S395 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18669648, 20068231
S396 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983, 20068231
S397 Phosphorylation HPRD 17287340, 17081983, 18767875, ...18452278, 19651622, 18669648, 20068231
S399 Phosphorylation HPRD 17287340, 17081983, 18767875, ...18452278, 19651622, 18669648, 20068231
S454 Phosphorylation HPRD 17287340, 17081983, 18767875, ...19651622, 18707149, 20068231
S458 Phosphorylation HPRD 19651622, 18767875, 17287340, ...20068231
S490 Phosphorylation HPRD 18669648, 20068231
S608 Phosphorylation HPRD 17525332
S625 Phosphorylation HPRD 19651622, 20166139, 17287340, ...17081983, 20068231
S652 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231
S664 Phosphorylation HPRD 16964243, 17287340, 17081983, ...19651622, 18669648, 20068231, 18212344
S671 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S137 Phosphorylation HPRD 19664994, 18212344, 18452278
S142 Phosphorylation HPRD 19651622
S144 Phosphorylation HPRD 19651622
S146 Phosphorylation HPRD 19651622
S149 Phosphorylation HPRD 19651622
S174 Phosphorylation HPRD 18452278
S175 Phosphorylation HPRD 18452278
T205 Phosphorylation HPRD 19651622
S230 Phosphorylation HPRD 19651622, 18669648, 20068231
S232 Phosphorylation HPRD 19651622, 18669648, 17287340, ...20068231
S234 Phosphorylation HPRD 19651622, 18669648, 17287340, ...20068231
S236 Phosphorylation HPRD 17287340, 20068231, 18452278
S240 Phosphorylation HPRD 17287340, 17081983, 18767875, ...18452278, 19651622, 18669648, 20068231
S366 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18669648, 20068231
S369 Phosphorylation HPRD 17287340, 17081983, 18767875, ...18452278, 19651622, 18669648, 20068231
S370 Phosphorylation HPRD 17287340, 17081983, 18767875, ...18452278, 19651622, 18669648, 20068231
S395 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18669648, 20068231
S396 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983, 20068231
S397 Phosphorylation HPRD 17287340, 17081983, 18767875, ...18452278, 19651622, 18669648, 20068231
S399 Phosphorylation HPRD 17287340, 17081983, 18767875, ...18452278, 19651622, 18669648, 20068231
S454 Phosphorylation HPRD 17287340, 17081983, 18767875, ...19651622, 18707149, 20068231
S458 Phosphorylation HPRD 19651622, 18767875, 17287340, ...20068231
S490 Phosphorylation HPRD 18669648, 20068231
S608 Phosphorylation HPRD 17525332
S625 Phosphorylation HPRD   PhosphoSitePlus 17287340, 17081983, 19651622, ...20166139, 20068231
S633 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
S651 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231, ...18767875
S663 Phosphorylation HPRD 16964243, 17287340, 17081983, ...19651622, 18669648, 20068231, 18212344
S670 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y18 S18 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y61 N61 Biomuta DOID:263 / kidney cancer [ cosmic ]
T159 M159 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S165 L165 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S174 F174 Biomuta DOID:4159 / skin cancer [ cosmic ]
S240 W240 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S255 F255 Biomuta DOID:4159 / skin cancer [ cosmic ]
S256 Y256 Biomuta DOID:3571 / liver cancer [ cosmic ]
S260 P260 Biomuta DOID:363 / uterine cancer [ cosmic ]
S260 F260 Biomuta DOID:4159 / skin cancer [ cosmic ]
S264 F264 Biomuta DOID:4159 / skin cancer [ cosmic ]
S266 C266 Biomuta [ cosmic ]
S305 I305 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S366 N366 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S396 F396 Biomuta DOID:1612 / breast cancer [ cosmic ]
S418 Y418 Biomuta DOID:1612 / breast cancer [ cosmic ]
S454 A454 Biomuta DOID:363 / uterine cancer [ cosmic ]
K487 N487 Biomuta DOID:363 / uterine cancer [ cosmic ]
C496 Y496 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S599 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
C631 Y631 Biomuta DOID:4159 / skin cancer [ cosmic ]
S633 F633 Biomuta DOID:4159 / skin cancer [ cosmic ]
S663 L663 Biomuta DOID:363 / uterine cancer [ cosmic ]
S664 L664 Biomuta DOID:363 / uterine cancer [ cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]