iPTMnet Report for Q7Z4S6 (KIF21A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z4S6 / KI21A_HUMAN
Protein Name Kinesin-like protein KIF21A
Gene Name Name: KIF21A
Synonyms:KIAA1708,KIF2;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z4S6
DAG View
PRO Name kinesin-like protein KIF21A (human)
Definition A kinesin-like protein KIF21A that is encoded in the genome of human.
Short Label hKIF21A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z4S6 (KIF21A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
S8 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
K542 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
T579 Phosphorylation PhosphoSitePlus
T581 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
Y678 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
T827 Phosphorylation PhosphoSitePlus
S841 Phosphorylation PhosphoSitePlus
T849 Phosphorylation PhosphoSitePlus
S853 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S854 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S855 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T862 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
S1046 Phosphorylation PhosphoSitePlus
K1051 Ubiquitination PhosphoSitePlus
K1058 Ubiquitination PhosphoSitePlus
T1157 Phosphorylation PhosphoSitePlus
T1158 Phosphorylation PhosphoSitePlus
S1212 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 20068231
S1219 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1228 Phosphorylation PhosphoSitePlus
S1229 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1239 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
T1242 Phosphorylation PhosphoSitePlus
K1249 Acetylation PhosphoSitePlus
S1261 Phosphorylation PhosphoSitePlus
T1265 Phosphorylation PhosphoSitePlus
S1271 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1274 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1275 Phosphorylation PhosphoSitePlus
S1278 Phosphorylation PhosphoSitePlus
S1293 Phosphorylation PhosphoSitePlus
S1298 Phosphorylation PhosphoSitePlus
S1304 Phosphorylation PhosphoSitePlus
S1307 Phosphorylation PhosphoSitePlus
S1317 Phosphorylation PhosphoSitePlus
S1318 Phosphorylation PhosphoSitePlus
S1662 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T1664 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S1673 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S524 Phosphorylation HPRD 20068231
S654 Phosphorylation HPRD 20068231
T660 Phosphorylation HPRD 20068231
S840 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18707149
S841 Phosphorylation HPRD 18669648
S842 Phosphorylation HPRD 18669648, 18707149
S852 Phosphorylation HPRD 17081983
S1199 Phosphorylation HPRD 19413330, 18669648, 19691289, ...20068231
S1210 Phosphorylation HPRD 19413330
S1212 Phosphorylation HPRD 19413330
S1216 Phosphorylation HPRD 19413330
S1226 Phosphorylation HPRD 19413330, 17322306, 18767875, ...19664994, 19691289, 19651622, 18669648, 20068231
T1229 Phosphorylation HPRD 19651622, 17081983
S1649 Phosphorylation HPRD 18669648, 19415658, 20068231
T1651 Phosphorylation HPRD 18669648, 20068231
S1660 Phosphorylation HPRD 18669648, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S1099 Phosphorylation PhosphoSitePlus
T1100 Phosphorylation PhosphoSitePlus
S1108 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K47 Q47 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K314 N314 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S458 G458 Biomuta DOID:263 / kidney cancer [ cosmic ]
S458 R458 Biomuta DOID:4159 / skin cancer [ cosmic ]
S520 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S705 L705 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S840 R840 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S841 L841 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S841 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S852 G852 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S853 R853 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S854 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S854 L854 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S865 G865 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1158 A1158 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1210 I1210 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1216 F1216 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1219 F1219 Biomuta DOID:1781 / thyroid cancer [ icgc ]
S1223 I1223 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1226 Y1226 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S1228 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1229 F1229 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1239 Y1239 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S1271 L1271 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1274 F1274 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1298 L1298 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1317 F1317 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1318 F1318 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1660 G1660 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1673 G1673 Biomuta DOID:9256 / colorectal cancer [ cosmic ]