iPTMnet Report for Q7Z4I7 (LIMS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z4I7 / LIMS2_HUMAN
Protein Name LIM and senescent cell antigen-like-containing domain protein 2
Gene Name Name: LIMS2
Synonyms:PINCH2;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z4I7
DAG View
PRO Name LIM and senescent cell antigen-like-containing domain protein 2 (human)
Definition A LIM and senescent cell antigen-like-containing domain protein 2 that is encoded in the genome of human.
Short Label hLIMS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z4I7 (LIMS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
F22 Phosphorylation UniProt 24275569
Y185 Phosphorylation PhosphoSitePlus
K229 Sumoylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
S324 O-Glycosylation GlyGen 30379171, 28510447
S324 Phosphorylation PhosphoSitePlus
T327 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S328 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y14 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S348 Phosphorylation HPRD 20068231
T351 Phosphorylation HPRD 18669648, 20068231
S352 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y185 D185 Biomuta DOID:363 / uterine cancer [ icgc ]
S324 L324 Biomuta DOID:1324 / lung cancer [ cosmic ]
S328 F328 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S348 L348 Biomuta DOID:1324 / lung cancer [ cosmic ]
S352 F352 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]