iPTMnet Report for Q7Z4G4 (TRMT11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z4G4 / TRM11_HUMAN
Protein Name tRNA (guanine(10)-N2)-methyltransferase homolog
Gene Name Name: TRMT11
Synonyms:C6orf75;ORFNames:MDS024;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z4G4
DAG View
PRO Name tRNA (guanine(10)-N2)-methyltransferase homolog (human)
Definition A tRNA guanosine-2'-O-methyltransferase TRM11 that is encoded in the genome of human.
Short Label hTRMT11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z4G4 (TRMT11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
C5 Methylation IEDB 31844290
Y44 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
K109 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
C233 Methylation IEDB 31844290
Y311 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
K452 Ubiquitination PhosphoSitePlus
T461 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation HPRD 17322306
Y44 Phosphorylation HPRD 15592455


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y44 H44 Biomuta DOID:363 / uterine cancer [ icgc ]
K324 T324 Biomuta DOID:263 / kidney cancer [ cosmic ]
S441 F441 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]