iPTMnet Report for Q7Z417 (NUFIP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z417 / NUFP2_HUMAN
Protein Name FMR1-interacting protein NUFIP2
Gene Name Name: NUFIP2
Synonyms:KIAA1321;ORFNames:PIG1;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z417
DAG View
PRO Name FMR1-interacting protein NUFIP2 (human)
Definition An FMR1-interacting protein NUFIP2 that is encoded in the genome of human.
Short Label hNUFIP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z417 (NUFIP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K74 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus   UniProt 20068231, 17924679
S107 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S112 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S113 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K136 Methylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K140 Acetylation PhosphoSitePlus
K140 Methylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K150 Acetylation PhosphoSitePlus
T151 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
T183 Phosphorylation PhosphoSitePlus
S212 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 19690332, 20068231, 17081983
S214 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S216 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y218 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T219 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18847512
T219 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T220 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 18847512
T220 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S230 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
K269 Methylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K281 Sumoylation PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
T289 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
R291 Methylation PhosphoSitePlus   UniProt 24129315
K293 Methylation PhosphoSitePlus
R301 Methylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus   UniProt 24275569
S311 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
K313 Acetylation PhosphoSitePlus
K322 Acetylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
T369 O-Glycosylation GlyGen 30379171, 22661428
T369 Phosphorylation PhosphoSitePlus
S373 O-Glycosylation GlyGen 30379171
S374 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
S374 Phosphorylation PhosphoSitePlus
S376 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
S376 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18220336
T378 O-Glycosylation GlyGen 30379171
T378 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S379 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
S379 Phosphorylation PhosphoSitePlus
S380 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
S381 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
S382 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
S382 Phosphorylation PhosphoSitePlus
S383 O-Glycosylation GlyGen 30379171
S384 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
S385 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
S386 O-Glycosylation GlyGen 30379171
S386 Phosphorylation PhosphoSitePlus
T387 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
T387 Phosphorylation PhosphoSitePlus
T390 Phosphorylation PhosphoSitePlus
S396 O-Glycosylation GlyGen 22661428
S404 Phosphorylation PhosphoSitePlus
T437 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
S510 Phosphorylation PhosphoSitePlus
Y540 Phosphorylation PhosphoSitePlus
S546 O-Glycosylation GlyGen 33214551, 35138101, 34019948, ...30379171, 27114449, 21740066, 35254053, 35132862, 30620550, 20305658, 32119511, 36240223, 29351928, 22661428
K569 Ubiquitination PhosphoSitePlus
T571 Phosphorylation PhosphoSitePlus   UniProt 20068231
S572 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...27920218, 18669648, 19690332, 20068231
S578 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus   UniProt 23186163
K603 Ubiquitination PhosphoSitePlus
S608 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
S616 Phosphorylation PhosphoSitePlus
Y619 Phosphorylation PhosphoSitePlus
S629 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 19690332, 20068231
T631 Phosphorylation PhosphoSitePlus
T633 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S637 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S652 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18220336, 15144186, 18669648, 19369195, 20068231
S655 Phosphorylation PhosphoSitePlus   UniProt 21406692
S692 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
T87 Phosphorylation HPRD 20068231, 17924679
S112 Phosphorylation HPRD 19413330, 17322306, 18767875, ...20058876, 19664995, 18452278, 19651622, 18669648, 20068231
S113 Phosphorylation HPRD 18669648, 19664994
S212 Phosphorylation HPRD 19413330, 17322306, 16964243, ...19664994, 19664995, 19651622, 18669648, 20068231, 18212344
S214 Phosphorylation HPRD 17322306, 19413330, 18669648, ...19651622, 20068231
S216 Phosphorylation HPRD 19651622, 18669648, 17081983
Y218 Phosphorylation HPRD 19413330, 18669648
T219 Phosphorylation HPRD 18669648
T220 Phosphorylation HPRD 19413330, 18669648, 16964243, ...20068231
T289 Phosphorylation HPRD 18212344
S376 Phosphorylation HPRD 19413330, 18669648, 19664995
T378 Phosphorylation HPRD 19413330, 18669648
T387 Phosphorylation HPRD 19413330
T390 Phosphorylation HPRD 19413330
S404 Phosphorylation HPRD 20068231
T571 Phosphorylation HPRD 19651622, 18691976, 19664995, ...20068231
S572 Phosphorylation HPRD 18691976, 18767875, 19664995, ...19651622, 17322306, 18669648, 19415658, 20068231, 17924679
S608 Phosphorylation HPRD 17525332
S629 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19664995, 18452278, 19651622, 18669648, 15345747, 19415658, 20068231, 17924679
T631 Phosphorylation HPRD 19413330
T633 Phosphorylation HPRD 17322306, 18669648, 19664995, ...20068231
S637 Phosphorylation HPRD 18669648
S652 Phosphorylation HPRD 19413330, 18691976, 18212344, ...20230923, 18767875, 20058876, 19664995, 18452278, 17322306, 19664994, 18669648, 19651622, 18707149, 19415658, 20068231
S692 Phosphorylation HPRD 18669648, 19664995, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S107 F107 Biomuta DOID:4159 / skin cancer [ cosmic ]
K146 N146 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K152 N152 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S214 F214 Biomuta DOID:4159 / skin cancer [ cosmic ]
S214 A214 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y218 C218 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y265 C265 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R291 Q291 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R291 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
R301 W301 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R301 L301 Biomuta DOID:1324 / lung cancer [ cosmic ]
K313 R313 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S333 L333 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K338 N338 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S373 F373 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S374 Y374 Biomuta DOID:363 / uterine cancer [ icgc ]
S380 F380 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S383 C383 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S385 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S386 Y386 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S510 L510 Biomuta DOID:4159 / skin cancer [ cosmic ]
T571 S571 Biomuta DOID:3571 / liver cancer [ cosmic ]
S586 G586 Biomuta DOID:3571 / liver cancer [ cosmic ]
S608 T608 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y619 C619 Biomuta DOID:3571 / liver cancer [ cosmic ]
T631 M631 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S655 F655 Biomuta DOID:4159 / skin cancer [ cosmic ]