iPTMnet Report for Q7Z403 (TMC6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z403 / TMC6_HUMAN
Protein Name Transmembrane channel-like protein 6
Gene Name Name: TMC6
Synonyms:EVER1,EVIN1;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z403
DAG View
PRO Name transmembrane channel-like protein 6 (human)
Definition A transmembrane channel-like protein 6 that is encoded in the genome of human.
Short Label hTMC6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z403 (TMC6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T60 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus   UniProt 23186163
R94 Methylation PhosphoSitePlus   UniProt 24129315
Y101 Phosphorylation PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus   UniProt 23186163
S127 Phosphorylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
C511 Methylation IEDB 31844290
K584 Ubiquitination PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
Y775 Phosphorylation PhosphoSitePlus
K778 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S420 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R94 Q94 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S127 I127 Biomuta DOID:1319 / brain cancer [ cosmic ]
K764 N764 Biomuta DOID:363 / uterine cancer [ icgc ]
K764 T764 Biomuta DOID:363 / uterine cancer [ icgc ]