iPTMnet Report for Q7Z402 (TMC7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z402 / TMC7_HUMAN
Protein Name Transmembrane channel-like protein 7
Gene Name Name: TMC7
Organism Homo sapiens (Human)

PRO ID PR:Q7Z402
DAG View
PRO Name transmembrane channel-like protein 7 (human)
Definition A transmembrane channel-like protein 7 that is encoded in the genome of human.
Short Label hTMC7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z402 (TMC7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
Y73 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y93 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
Y381 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K68 M68 Biomuta DOID:3571 / liver cancer [ cosmic ]
S89 F89 Biomuta DOID:4159 / skin cancer [ cosmic ]
S321 N321 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]