Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z3V4 / UBE3B_HUMAN
Protein Name Ubiquitin-protein ligase E3B
Gene Name Name: UBE3B
Organism Homo sapiens (Human)

PRO ID PR:Q7Z3V4
DAG View
PRO Name ubiquitin-protein ligase E3B (human)
Definition A ubiquitin-protein ligase E3B that is encoded in the genome of human.
Short Label hUBE3B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z3V4 (UBE3B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S102 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
T164 Phosphorylation phospho.ELM 17081983
S419 Phosphorylation PhosphoSitePlus   UniProt 18691976
K427 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K450 Acetylation PhosphoSitePlus
K622 Ubiquitination PhosphoSitePlus
Y643 Phosphorylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus
Y695 Phosphorylation PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus
Y787 Phosphorylation PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
T940 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S419 Phosphorylation HPRD 18691976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K149 R149 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K427 N427 Biomuta DOID:363 / uterine cancer [ tcga ]
S675 F675 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y695 C695 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S925 A925 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]