iPTMnet Report for Q7Z3C6 (ATG9A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z3C6 / ATG9A_HUMAN
Protein Name Autophagy-related protein 9A
Gene Name Name: ATG9A
Synonyms:APG9L1;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z3C6
DAG View
PRO Name autophagy-related protein 9A (human)
Definition An autophagy-related protein 9A that is encoded in the genome of human.
Short Label hATG9A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z3C6 (ATG9A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
Y8 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 27934868
S14 Phosphorylation O75385 (ULK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 23186163, 27934868
Y15 Phosphorylation PhosphoSitePlus
S16 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S18 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
N99 N-Glycosylation GlyGen   UniProt 16940348, 24190977, 27316455
K192 Ubiquitination PhosphoSitePlus
Y209 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
T518 O-Glycosylation GlyGen 29237092
S543 Phosphorylation PhosphoSitePlus
Y545 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus
R645 Methylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
S654 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S656 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S675 Phosphorylation PhosphoSitePlus
S735 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...24275569
S738 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648
S741 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18669648
S755 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus
S761 Phosphorylation Q13131 (PRKAA1) , O75385 (ULK1) PhosphoSitePlus   RLIMS-P   Signor 25266655
R784 Methylation PhosphoSitePlus
Y785 Phosphorylation PhosphoSitePlus
S799 Phosphorylation PhosphoSitePlus
S828 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 19651622, 18669648
S16 Phosphorylation HPRD 19651622, 18669648
S18 Phosphorylation HPRD 19651622, 18669648, 20068231
S33 Phosphorylation HPRD 19651622
S654 Phosphorylation HPRD 18669648, 20068231
S656 Phosphorylation HPRD 18669648, 20068231
S735 Phosphorylation HPRD 19651622, 18669648
S738 Phosphorylation HPRD 18669648
S741 Phosphorylation HPRD 18669648
S828 Phosphorylation HPRD 19651622, 18578522, 18669648, ...20068231, 17081983


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q7Z3C6 (ATG9A) S761 P63104 (YWHAZ) increased_association eFIP 25266655


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y545 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S642 F642 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R645 M645 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S675 C675 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S755 Y755 Biomuta DOID:363 / uterine cancer [ icgc ]
R784 C784 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S799 C799 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S828 L828 Biomuta DOID:4159 / skin cancer [ cosmic ]