iPTMnet Report for Q7Z333 (SETX)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z333 / SETX_HUMAN
Protein Name Probable helicase senataxin
Gene Name Name: SETX
Synonyms:ALS4,KIAA0625,SCAR1;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z333
DAG View
PRO Name probable helicase senataxin (human)
Definition A probable helicase senataxin that is encoded in the genome of human.
Short Label hSETX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z333 (SETX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K78 Sumoylation PhosphoSitePlus
K109 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
R332 Methylation PhosphoSitePlus
R337 Methylation PhosphoSitePlus
K339 Sumoylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
T372 Phosphorylation PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
T455 Phosphorylation IEDB 35494241
K556 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
S615 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S618 O-Glycosylation GlyGen 30379171, 29351928
Y619 Phosphorylation PhosphoSitePlus
K621 Sumoylation PhosphoSitePlus
K621 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
S642 Phosphorylation PhosphoSitePlus   UniProt 23186163
K651 Sumoylation PhosphoSitePlus
K651 Ubiquitination PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
K675 Sumoylation PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
K678 Sumoylation PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
K833 Ubiquitination PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
K857 Ubiquitination PhosphoSitePlus
S858 Phosphorylation PhosphoSitePlus
K894 Sumoylation PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
T900 Phosphorylation PhosphoSitePlus
T903 Phosphorylation PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
K908 Ubiquitination PhosphoSitePlus
S910 Phosphorylation PhosphoSitePlus
S911 Phosphorylation PhosphoSitePlus   UniProt 23186163
K914 Ubiquitination PhosphoSitePlus
S928 Phosphorylation PhosphoSitePlus
S947 Phosphorylation PhosphoSitePlus   UniProt 23186163
K949 Ubiquitination PhosphoSitePlus
S950 Phosphorylation PhosphoSitePlus
T952 Phosphorylation PhosphoSitePlus
T954 Phosphorylation PhosphoSitePlus
S956 Phosphorylation PhosphoSitePlus   UniProt 23186163
K964 Ubiquitination PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
S1017 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...24275569, 19690332, 20068231
S1019 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...24275569, 20068231
K1032 Ubiquitination PhosphoSitePlus
K1038 Ubiquitination PhosphoSitePlus
S1055 O-Glycosylation GlyGen 30379171, 29351928
K1056 Ubiquitination PhosphoSitePlus
K1063 Sumoylation PhosphoSitePlus
K1109 Sumoylation PhosphoSitePlus
K1109 Ubiquitination PhosphoSitePlus
K1133 Ubiquitination PhosphoSitePlus
S1146 Phosphorylation IEDB   PhosphoSitePlus 27920218
S1148 Phosphorylation PhosphoSitePlus
K1167 Ubiquitination PhosphoSitePlus
K1190 Ubiquitination PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
S1224 Phosphorylation PhosphoSitePlus
T1230 Phosphorylation PhosphoSitePlus
S1239 Phosphorylation PhosphoSitePlus
Y1297 Phosphorylation PhosphoSitePlus
S1300 Phosphorylation PhosphoSitePlus
S1303 Phosphorylation PhosphoSitePlus
Y1306 Phosphorylation PhosphoSitePlus
K1315 Ubiquitination PhosphoSitePlus
K1324 Ubiquitination PhosphoSitePlus
K1325 Ubiquitination PhosphoSitePlus
S1330 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1335 Phosphorylation PhosphoSitePlus
K1341 Sumoylation PhosphoSitePlus
S1366 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1370 Phosphorylation PhosphoSitePlus
T1371 Phosphorylation PhosphoSitePlus
K1550 Acetylation PhosphoSitePlus
K1552 Acetylation PhosphoSitePlus
K1552 Ubiquitination PhosphoSitePlus
T1557 Phosphorylation PhosphoSitePlus
T1558 Phosphorylation PhosphoSitePlus
K1572 Ubiquitination PhosphoSitePlus
K1590 Acetylation PhosphoSitePlus
K1602 Ubiquitination PhosphoSitePlus
S1611 Phosphorylation PhosphoSitePlus
K1612 Ubiquitination PhosphoSitePlus
S1613 Phosphorylation PhosphoSitePlus
S1621 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16964243
S1623 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1625 Methylation PhosphoSitePlus
K1625 Ubiquitination PhosphoSitePlus
K1627 Methylation PhosphoSitePlus
K1629 Ubiquitination PhosphoSitePlus
K1636 Ubiquitination PhosphoSitePlus
K1647 Acetylation PhosphoSitePlus
K1647 Ubiquitination PhosphoSitePlus
K1653 Ubiquitination PhosphoSitePlus
S1663 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1667 Phosphorylation PhosphoSitePlus
K1673 Ubiquitination PhosphoSitePlus
K1680 Ubiquitination PhosphoSitePlus
K1806 Ubiquitination PhosphoSitePlus
K1823 Ubiquitination PhosphoSitePlus
K1843 Ubiquitination PhosphoSitePlus
T1847 Phosphorylation PhosphoSitePlus
S1860 Phosphorylation PhosphoSitePlus
S1898 Phosphorylation PhosphoSitePlus
K1917 Ubiquitination PhosphoSitePlus
K1940 Ubiquitination PhosphoSitePlus
K1950 Ubiquitination PhosphoSitePlus
K1957 Ubiquitination PhosphoSitePlus
K1969 Ubiquitination PhosphoSitePlus
S1970 Phosphorylation PhosphoSitePlus
K1971 Ubiquitination PhosphoSitePlus
Y1978 Phosphorylation PhosphoSitePlus
K1997 Ubiquitination PhosphoSitePlus
K2025 Ubiquitination PhosphoSitePlus
K2027 Methylation PhosphoSitePlus
K2032 Ubiquitination PhosphoSitePlus
K2050 Ubiquitination PhosphoSitePlus
K2058 Ubiquitination PhosphoSitePlus
K2071 Ubiquitination PhosphoSitePlus
S2075 Phosphorylation PhosphoSitePlus
K2084 Ubiquitination PhosphoSitePlus
K2118 Ubiquitination PhosphoSitePlus
K2129 Ubiquitination PhosphoSitePlus
K2131 Ubiquitination PhosphoSitePlus
K2201 Ubiquitination PhosphoSitePlus
T2255 Phosphorylation PhosphoSitePlus
Y2258 Phosphorylation PhosphoSitePlus
K2349 Ubiquitination PhosphoSitePlus
K2357 Ubiquitination PhosphoSitePlus
K2366 Sumoylation PhosphoSitePlus
K2366 Ubiquitination PhosphoSitePlus
K2443 Ubiquitination PhosphoSitePlus
K2449 Ubiquitination PhosphoSitePlus
K2461 Ubiquitination PhosphoSitePlus
K2464 Ubiquitination PhosphoSitePlus
K2466 Ubiquitination PhosphoSitePlus
S2472 Phosphorylation PhosphoSitePlus
T2474 Phosphorylation PhosphoSitePlus   UniProt 23186163
K2494 Ubiquitination PhosphoSitePlus
K2501 Methylation PhosphoSitePlus
K2501 Ubiquitination PhosphoSitePlus
S2612 Phosphorylation PhosphoSitePlus
S2639 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S615 Phosphorylation HPRD 18669648
S642 Phosphorylation HPRD 18767875, 17081983
S646 Phosphorylation HPRD 18767875
T722 Phosphorylation HPRD 17081983
S956 Phosphorylation HPRD 19007248
S1017 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 19415658, 20068231
S1019 Phosphorylation HPRD 17081983, 18452278, 19651622, ...18669648, 19415658, 20068231
S1330 Phosphorylation HPRD 18691976, 19007248, 19691289
S1366 Phosphorylation HPRD 18212344, 20068231
S1370 Phosphorylation HPRD 18452278
T1371 Phosphorylation HPRD 18452278
S1621 Phosphorylation HPRD 16964243, 19007248
S1663 Phosphorylation HPRD 20068231
S1667 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K75 Q75 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R332 W332 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
Y378 D378 Biomuta DOID:263 / kidney cancer [ cosmic ]
T455 S455 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K556 R556 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K561 T561 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S615 Y615 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K629 E629 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K716 R716 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T954 M954 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S956 F956 Biomuta DOID:4159 / skin cancer [ cosmic ]
S956 T956 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1017 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1055 N1055 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1300 F1300 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1300 P1300 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1303 F1303 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1366 P1366 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1602 N1602 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1613 Y1613 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1629 R1629 Biomuta DOID:1319 / brain cancer [ cosmic ]
K1957 N1957 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1970 L1970 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K2027 Q2027 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K2032 N2032 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K2084 N2084 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K2131 E2131 Biomuta DOID:4159 / skin cancer [ cosmic ]
K2201 R2201 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S2612 G2612 Biomuta DOID:1324 / lung cancer [ icgc ]
S2639 T2639 Biomuta DOID:1324 / lung cancer [ cosmic ]