iPTMnet Report for Q7Z2Y5 (NRK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z2Y5 / NRK_HUMAN
Protein Name Nik-related protein kinase
Gene Name Name: NRK
Organism Homo sapiens (Human)

PRO ID PR:Q7Z2Y5
DAG View
PRO Name Nik-related protein kinase (human)
Definition A Nik-related protein kinase that is encoded in the genome of human.
Short Label hNRK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z2Y5 (NRK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T30 O-Glycosylation GlyGen 35289036, 30059200
T35 O-Glycosylation GlyGen 35289036, 30059200
S211 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
T327 Phosphorylation PhosphoSitePlus
T331 O-Glycosylation GlyGen 35289036, 30059200
T331 Phosphorylation PhosphoSitePlus
K702 Acetylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
K818 Methylation PhosphoSitePlus
S852 Phosphorylation PhosphoSitePlus   UniProt 21406692
S855 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y858 Phosphorylation PhosphoSitePlus
S859 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
Y885 Phosphorylation PhosphoSitePlus
Y893 Phosphorylation PhosphoSitePlus
Y984 Phosphorylation PhosphoSitePlus
Y985 Phosphorylation PhosphoSitePlus
Y1016 Phosphorylation PhosphoSitePlus
S1027 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1031 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1034 Phosphorylation PhosphoSitePlus   UniProt 21406692
S1057 Phosphorylation PhosphoSitePlus
S1084 Phosphorylation PhosphoSitePlus
Y1191 Phosphorylation PhosphoSitePlus
T1242 Phosphorylation PhosphoSitePlus
S1359 Phosphorylation PhosphoSitePlus
S1362 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S855 Phosphorylation HPRD 19664995


Q7Z2Y5 (NRK) as PTM Enzyme



Substrate Site Score Source PMID
P23528 (CFL1) S3 HPRD 11340065, 19413330, 18578522, ...18491316, 18702456, 9655398, 20058876, 19651622, 18669648, 11925442, 11418599, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S709 L709 Biomuta DOID:4159 / skin cancer [ icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
S855 P855 Biomuta DOID:4159 / skin cancer [ cosmic ]
S881 L881 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S1027 I1027 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1031 N1031 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1057 R1057 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1191 C1191 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T1242 I1242 Biomuta DOID:1324 / lung cancer [ cosmic ]