Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z2W4 / ZCCHV_HUMAN
Protein Name Zinc finger CCCH-type antiviral protein 1
Gene Name Name: ZC3HAV1
Synonyms:ZC3HDC2;ORFNames:PRO1677;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z2W4
DAG View
PRO Name zinc finger CCCH-type antiviral protein 1 (human)
Definition A zinc finger CCCH-type antiviral protein 1 that is encoded in the genome of human.
Short Label hZC3HAV1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z2W4 (ZC3HAV1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
K12 Ubiquitination PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
Y98 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K151 Acetylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
R179 Methylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 26001115, 23186163, 19690332
S267 Phosphorylation PhosphoSitePlus
S271 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
C272 S-Nitrosylation dbSNO 26338901
T273 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S275 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569, ...18220336
S280 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S284 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 16964243, ...18220336, 18669648, 24275569, 26001115, 19690332, 20068231, 17081983
T294 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
Y299 Phosphorylation PhosphoSitePlus
S302 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S310 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
S335 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18669648, 26001115, ...19690332, 20068231
S346 Phosphorylation PhosphoSitePlus
T347 Phosphorylation PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus
N352 N-Glycosylation GlyGen 24190977
T354 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus   UniProt 23186163
K360 Methylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
K374 Methylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus   RLIMS-P 26001115
S378 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18220336, 15302935, ...18669648, 26001115, 18088087, 20068231
T380 Phosphorylation PhosphoSitePlus
R385 Methylation PhosphoSitePlus
S386 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S387 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 18220336
S390 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T393 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...19690332, 20068231
T398 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
T403 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus   UniProt 23186163
S408 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y410 Phosphorylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
Y447 Phosphorylation PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus   UniProt 23186163
S492 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S494 Phosphorylation PhosphoSitePlus   UniProt 23186163
C513 S-Nitrosylation dbSNO 26338901
C518 S-Nitrosylation dbSNO 26338901
K519 Ubiquitination PhosphoSitePlus
T547 Phosphorylation PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus   UniProt 23186163
S580 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus   UniProt 23186163
K597 Ubiquitination PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
Y642 Phosphorylation PhosphoSitePlus
C645 S-Nitrosylation dbSNO 26338901
T669 O-Glycosylation GlyGen 23301498, 27655845, 28314751, ...29351928, 32119511, 28510447
S673 O-Glycosylation GlyGen 23301498, 27655845, 28314751, ...29351928, 32119511, 28510447
K677 Ubiquitination PhosphoSitePlus
Y690 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
T711 Phosphorylation PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
Y740 Phosphorylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
K752 Ubiquitination PhosphoSitePlus
K761 Ubiquitination PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
K770 Ubiquitination PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus
S796 Phosphorylation RLIMS-P 26001115
K816 Ubiquitination PhosphoSitePlus
K822 Ubiquitination PhosphoSitePlus
Y826 Phosphorylation PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
S872 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T61 Phosphorylation HPRD 20068230
S257 Phosphorylation HPRD 19413330, 18077418, 19415658
S271 Phosphorylation HPRD 18767875, 18669648, 17081983
T273 Phosphorylation HPRD 17322306, 19413330, 18669648, ...19664994, 19415658
S275 Phosphorylation HPRD 19413330, 18767875, 19664994, ...17322306, 18669648, 19415658
S280 Phosphorylation HPRD 18669648
S284 Phosphorylation HPRD 16964243, 19664994, 19664995, ...18452278, 19651622, 18669648, 20166139, 20068231, 17081983
T298 Phosphorylation HPRD 20068231
S302 Phosphorylation HPRD 19651622, 18669648, 20068231
S312 Phosphorylation HPRD 20068231
S335 Phosphorylation HPRD 18077418, 18669648, 20068231, ...18452278
T375 Phosphorylation HPRD 20058876
S378 Phosphorylation HPRD 19413330, 18691976, 18088087, ...16964243, 18767875, 19664994, 19664995, 19651622, 18669648, 20058876, 17924679, 19415658, 20068231, 20068230
S386 Phosphorylation HPRD 19413330, 18691976, 19664995, ...18669648, 20166139, 20068231
S387 Phosphorylation HPRD 19413330, 18669648, 20058876, ...20068231, 17924679
S390 Phosphorylation HPRD 19413330, 18669648, 20068231
T393 Phosphorylation HPRD 19413330, 16964243, 18669648, ...19415658, 20068231, 17924679
S408 Phosphorylation HPRD 18669648
S492 Phosphorylation HPRD 20068231
S673 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T61 Phosphorylation HPRD 20068230
S257 Phosphorylation HPRD 19413330, 18077418, 19415658
S271 Phosphorylation HPRD 18767875, 18669648, 17081983
T273 Phosphorylation HPRD 17322306, 19413330, 18669648, ...19664994, 19415658
S275 Phosphorylation HPRD 19413330, 18767875, 19664994, ...17322306, 18669648, 19415658
S280 Phosphorylation HPRD 18669648
S284 Phosphorylation HPRD 16964243, 19664994, 19664995, ...18452278, 19651622, 18669648, 20166139, 20068231, 17081983
T298 Phosphorylation HPRD 20068231
S302 Phosphorylation HPRD 19651622, 18669648, 20068231
S312 Phosphorylation HPRD 20068231
S335 Phosphorylation HPRD 18077418, 18669648, 20068231, ...18452278
T375 Phosphorylation HPRD 20058876
S378 Phosphorylation HPRD 19413330, 18691976, 18088087, ...16964243, 18767875, 19664994, 19664995, 19651622, 18669648, 20058876, 17924679, 19415658, 20068231, 20068230
S386 Phosphorylation HPRD 19413330, 18691976, 19664995, ...18669648, 20166139, 20068231
S387 Phosphorylation HPRD 19413330, 18669648, 20058876, ...20068231, 17924679
S390 Phosphorylation HPRD 19413330, 18669648, 20068231
T393 Phosphorylation HPRD 19413330, 16964243, 18669648, ...19415658, 20068231, 17924679
S408 Phosphorylation HPRD 18669648
S492 Phosphorylation HPRD 20068231
S673 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
R477 Methylation PhosphoSitePlus
R485 Methylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K89 T89 Biomuta DOID:363 / uterine cancer [ tcga ]
S109 Y109 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S114 * Biomuta DOID:3571 / liver cancer [ icgc ]
K154 Q154 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S221 R221 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S235 Y235 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S257 N257 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S257 C257 Biomuta DOID:0070003 / blastoma [ cosmic ]
S312 L312 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K314 N314 Biomuta DOID:1324 / lung cancer [ cosmic ]
S346 I346 Biomuta DOID:263 / kidney cancer [ tcga ]
T347 N347 Biomuta DOID:3571 / liver cancer [ icgc ]
T354 I354 Biomuta DOID:0070003 / blastoma [ cosmic ]
S355 * Biomuta DOID:1324 / lung cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
T363 A363 Biomuta DOID:2531 / hematologic cancer [ tcga ]
T380 M380 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R385 C385 Biomuta DOID:1324 / lung cancer [ cosmic ]
T393 P393 Biomuta DOID:1324 / lung cancer [ tcga ]
K401 R401 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S469 F469 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S492 Y492 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T547 A547 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K597 T597 Biomuta DOID:363 / uterine cancer [ tcga ]
S673 Y673 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K726 N726 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K729 E729 Biomuta DOID:363 / uterine cancer [ tcga ]
K770 R770 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S872 L872 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ icgc, tcga ]