iPTMnet Report for Q7Z2K6 (ERMP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7Z2K6 / ERMP1_HUMAN
Protein Name Endoplasmic reticulum metallopeptidase 1
Gene Name Name: ERMP1
Synonyms:FXNA;
Organism Homo sapiens (Human)

PRO ID PR:Q7Z2K6
DAG View
PRO Name endoplasmic reticulum metallopeptidase 1 (human)
Definition An endoplasmic reticulum metallopeptidase 1 that is encoded in the genome of human.
Short Label hERMP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7Z2K6 (ERMP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
C43 S-Nitrosylation dbSNO 26338901
S44 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
R362 Methylation PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
Y422 Phosphorylation PhosphoSitePlus
Y431 Phosphorylation PhosphoSitePlus
K704 Ubiquitination PhosphoSitePlus
N730 N-Glycosylation GlyGen   UniProt 19159218, 24190977
K758 Acetylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
S768 Phosphorylation PhosphoSitePlus
K780 Ubiquitination PhosphoSitePlus
N819 N-Glycosylation GlyGen 29741879, 24190977
K883 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S53 Phosphorylation HPRD 19651622, 20068231
S61 Phosphorylation HPRD 19651622, 20068231
S418 Phosphorylation HPRD 20068231
Y431 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S326 L326 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K356 N356 Biomuta DOID:263 / kidney cancer [ cosmic ]
R362 * Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S392 C392 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K393 T393 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
N730 S730 Biomuta DOID:4159 / skin cancer [ cosmic ]
S768 F768 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]