Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7RTS7 / K2C74_HUMAN
Protein Name Keratin, type II cytoskeletal 74
Gene Name Name: KRT74
Synonyms:K6IRS4,KB37,KRT5C,KRT6IRS4;
Organism Homo sapiens (Human)

PRO ID PR:Q7RTS7
DAG View
PRO Name keratin, type II cytoskeletal 74 (human)
Definition A keratin, type II cytoskeletal 74 that is encoded in the genome of human.
Short Label hKRT74
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7RTS7 (KRT74) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
K145 Methylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
S218 Phosphorylation HPRD   PhosphoSitePlus 19413330
Y226 Phosphorylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
K324 Acetylation PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
K336 Acetylation PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
Y425 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus
R452 Methylation PhosphoSitePlus
T513 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 20068231
S517 Phosphorylation PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 L20 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K157 N157 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K324 R324 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T335 I335 Biomuta DOID:363 / uterine cancer [ tcga ]
S356 N356 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S430 N430 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S430 C430 Biomuta DOID:10534 / stomach cancer [ tcga ]
S430 G430 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]