iPTMnet Report for Q7LGA3 (HS2ST1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7LGA3 / HS2ST_HUMAN
Protein Name Heparan sulfate 2-O-sulfotransferase 1
Gene Name Name: HS2ST1
Synonyms:HS2ST,KIAA0448;
Organism Homo sapiens (Human)

PRO ID PR:Q7LGA3
DAG View
PRO Name heparan sulfate 2-O-sulfotransferase 1 (human)
Definition A heparan sulfate 2-O-sulfotransferase 1 that is encoded in the genome of human.
Short Label hHS2ST1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7LGA3 (HS2ST1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N108 N-Glycosylation GlyGen 23090970, 29741879, 24190977
R123 Methylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
N127 N-Glycosylation GlyGen 24190977
R164 Methylation PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
Y340 Phosphorylation PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R123 H123 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
R123 C123 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K126 N126 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K298 E298 Biomuta DOID:1324 / lung cancer [ cosmic ]