Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7LDG7 / GRP2_HUMAN
Protein Name RAS guanyl-releasing protein 2
Gene Name Name: RASGRP2
Synonyms:CDC25L,MCG7;
Organism Homo sapiens (Human)

PRO ID PR:Q7LDG7
DAG View
PRO Name RAS guanyl-releasing protein 2 (human)
Definition A RAS guanyl-releasing protein 2 that is encoded in the genome of human.
Short Label hRASGRP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7LDG7 (RASGRP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus   RLIMS-P 28952923
K259 Ubiquitination PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus
S394 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   RLIMS-P+ 27107697
K415 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
R585 Methylation PhosphoSitePlus
S587 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 23611601
Site PTM Type PTM Enzyme Score Source PMID
S116 Phosphorylation HPRD 18452278
S576 Phosphorylation HPRD 20058876
Site PTM Type PTM Enzyme Score Source PMID
Y108 Phosphorylation PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
Y189 Phosphorylation PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
R643 Methylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
T661 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K65 N65 Biomuta DOID:4159 / skin cancer [ icgc ]
K74 E74 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S117 N117 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K128 N128 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S394 R394 Biomuta DOID:3571 / liver cancer [ icgc ]
S554 I554 Biomuta DOID:363 / uterine cancer [ tcga ]
S554 N554 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S576 N576 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S578 F578 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R585 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ tcga ]