iPTMnet Report for Q7LBC6 (KDM3B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7LBC6 / KDM3B_HUMAN
Protein Name Lysine-specific demethylase 3B
Gene Name Name: KDM3B
Synonyms:C5orf7,JHDM2B,JMJD1B,KIAA1082;
Organism Homo sapiens (Human)

PRO ID PR:Q7LBC6
DAG View
PRO Name lysine-specific demethylase 3B (human)
Definition A lysine-specific demethylase 3B that is encoded in the genome of human.
Short Label hKDM3B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7LBC6 (KDM3B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S7 Phosphorylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
R143 Methylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S291 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S299 Phosphorylation PhosphoSitePlus
K300 Acetylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
R355 Methylation PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
K361 Acetylation PhosphoSitePlus   UniProt 19608861
T366 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
T378 Phosphorylation PhosphoSitePlus
S381 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
T383 Phosphorylation PhosphoSitePlus
S386 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
T392 Phosphorylation PhosphoSitePlus
T409 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 30379171, 32574038, 34725712, 28510447, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S420 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
T425 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 30379171, 32574038, 34725712, 28510447, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
T426 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 30379171, 32574038, 34725712, 28510447, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S428 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S429 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
T430 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
T433 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S437 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 30379171, 32574038, 34725712, 28510447, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S437 Phosphorylation PhosphoSitePlus
T439 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S465 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S469 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S470 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S480 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 30379171, 32574038, 34725712, 28510447, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S480 Phosphorylation PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus   UniProt 23186163
K501 Acetylation PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus   UniProt 23186163
C569 Methylation IEDB 31844290
K570 Ubiquitination PhosphoSitePlus
S573 Phosphorylation PhosphoSitePlus
T579 Phosphorylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
K592 Sumoylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
T614 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S647 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28510447, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S647 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S650 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S651 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...32938750, 35138101, 35254053, 30379171, 32574038, 34725712, 28510447, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S654 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 30379171, 32574038, 34725712, 28510447, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S654 Phosphorylation phospho.ELM 18669648
S657 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28510447, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S659 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 30379171, 32574038, 34725712, 28510447, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S660 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28510447, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S661 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
T667 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S668 O-Glycosylation GlyGen 23301498, 34846842, 33214551, ...28510447, 35138101, 35254053, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S679 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 30379171, 32574038, 34725712, 28510447, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
K688 Ubiquitination PhosphoSitePlus
T696 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...35138101, 35254053, 30379171, 32574038, 34725712, 28510447, 34019948, 30059200, 35132862, 30620550, 31492838, 34931806, 32119511, 35289036, 29351928, 22661428, 29237092
S703 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus
T711 Phosphorylation PhosphoSitePlus
S725 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S726 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S727 Phosphorylation IEDB   phospho.ELM 18669648, 32387766
T729 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S730 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S731 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T733 Phosphorylation PhosphoSitePlus
T740 Phosphorylation PhosphoSitePlus
S742 Phosphorylation phospho.ELM 18669648
S743 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S744 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T751 Phosphorylation PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus   UniProt 23186163
R771 Methylation PhosphoSitePlus
S773 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S778 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S779 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S784 Phosphorylation PhosphoSitePlus
K788 Sumoylation PhosphoSitePlus
K788 Ubiquitination PhosphoSitePlus
K795 Acetylation PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
S798 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
K835 Ubiquitination PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
K859 Ubiquitination PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus
K892 Ubiquitination PhosphoSitePlus
K913 Ubiquitination PhosphoSitePlus
K924 Ubiquitination PhosphoSitePlus
K926 Methylation PhosphoSitePlus
K926 Ubiquitination PhosphoSitePlus
K1121 Ubiquitination PhosphoSitePlus
T1171 Phosphorylation PhosphoSitePlus
T1172 Phosphorylation PhosphoSitePlus
K1193 Ubiquitination PhosphoSitePlus
T1194 Phosphorylation PhosphoSitePlus
S1196 Phosphorylation PhosphoSitePlus
S1197 Phosphorylation PhosphoSitePlus
S1199 Phosphorylation PhosphoSitePlus
S1203 Phosphorylation PhosphoSitePlus
K1206 Ubiquitination PhosphoSitePlus
K1232 Ubiquitination PhosphoSitePlus
S1245 Phosphorylation PhosphoSitePlus
K1249 Ubiquitination PhosphoSitePlus
S1251 Phosphorylation PhosphoSitePlus
S1253 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1259 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1262 Phosphorylation PhosphoSitePlus
T1263 Phosphorylation PhosphoSitePlus
K1265 Ubiquitination PhosphoSitePlus
S1267 Phosphorylation PhosphoSitePlus
T1270 Phosphorylation PhosphoSitePlus
K1272 Acetylation PhosphoSitePlus
K1272 Ubiquitination PhosphoSitePlus
S1276 Phosphorylation PhosphoSitePlus
S1284 Phosphorylation PhosphoSitePlus
K1287 Ubiquitination PhosphoSitePlus
T1288 Phosphorylation PhosphoSitePlus
S1299 Phosphorylation PhosphoSitePlus
K1303 Ubiquitination PhosphoSitePlus
T1307 Phosphorylation PhosphoSitePlus
T1311 Phosphorylation PhosphoSitePlus
K1327 Ubiquitination PhosphoSitePlus
K1329 Ubiquitination PhosphoSitePlus
S1331 Phosphorylation PhosphoSitePlus
K1347 Ubiquitination PhosphoSitePlus
K1354 Ubiquitination PhosphoSitePlus
K1364 Ubiquitination PhosphoSitePlus
K1399 Ubiquitination PhosphoSitePlus
K1410 Ubiquitination PhosphoSitePlus
K1422 Ubiquitination PhosphoSitePlus
K1425 Ubiquitination PhosphoSitePlus
K1430 Ubiquitination PhosphoSitePlus
K1458 Ubiquitination PhosphoSitePlus
K1471 Ubiquitination PhosphoSitePlus
K1484 Ubiquitination PhosphoSitePlus
K1486 Ubiquitination PhosphoSitePlus
K1516 Ubiquitination PhosphoSitePlus
Y1541 Phosphorylation RLIMS-P 23593242
K1600 Ubiquitination PhosphoSitePlus
K1620 Ubiquitination PhosphoSitePlus
K1631 Ubiquitination PhosphoSitePlus
S1706 Phosphorylation PhosphoSitePlus
K1711 Ubiquitination PhosphoSitePlus
K1733 Ubiquitination PhosphoSitePlus
K1752 Methylation PhosphoSitePlus
K1752 Ubiquitination PhosphoSitePlus
K1757 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S289 Phosphorylation HPRD 19651622
S647 Phosphorylation HPRD 18669648
S654 Phosphorylation HPRD 18669648
S725 Phosphorylation HPRD 18669648, 20068231
S726 Phosphorylation HPRD 18669648
S727 Phosphorylation HPRD 18669648
T729 Phosphorylation HPRD 18669648, 20068231
S730 Phosphorylation HPRD 18669648
S731 Phosphorylation HPRD 18669648
S742 Phosphorylation HPRD 18669648
S743 Phosphorylation HPRD 18669648, 20068231
S744 Phosphorylation HPRD 18669648, 20068231
S766 Phosphorylation HPRD 18212344, 20068231
S773 Phosphorylation HPRD 19651622, 18669648, 20068231
S778 Phosphorylation HPRD 18669648
S779 Phosphorylation HPRD 18669648, 20068231
S798 Phosphorylation HPRD 17081983, 20068231, 18212344
S810 Phosphorylation HPRD 20068231
T814 Phosphorylation HPRD 20068231
S819 Phosphorylation HPRD 20068231
S822 Phosphorylation HPRD 20068231
T832 Phosphorylation HPRD 20068231
S1251 Phosphorylation HPRD 20068231
S1253 Phosphorylation HPRD 18669648, 20068231
S1267 Phosphorylation HPRD 19413330, 20068231
T1270 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R143 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T263 M263 Biomuta DOID:363 / uterine cancer [ icgc ]
S299 T299 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S314 N314 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R355 S355 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S386 Y386 Biomuta DOID:363 / uterine cancer [ icgc ]
T425 P425 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T425 I425 Biomuta DOID:4159 / skin cancer [ cosmic ]
S428 R428 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S429 A429 Biomuta [ cosmic ]
S455 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S465 Y465 Biomuta DOID:363 / uterine cancer [ icgc ]
S492 C492 Biomuta DOID:3571 / liver cancer [ cosmic ]
S551 F551 Biomuta DOID:4159 / skin cancer [ cosmic ]
S556 L556 Biomuta DOID:1324 / lung cancer [ cosmic ]
S573 F573 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T579 S579 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S588 F588 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
T614 A614 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S654 F654 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S657 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S679 C679 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S727 L727 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S730 N730 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T740 S740 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T751 A751 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T751 I751 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S773 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S784 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K788 E788 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S810 L810 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S819 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
T832 I832 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K876 N876 Biomuta DOID:3571 / liver cancer [ cosmic ]
K926 E926 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K1121 N1121 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1197 L1197 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K1206 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S1259 L1259 Biomuta DOID:363 / uterine cancer [ icgc ]
S1299 F1299 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1327 N1327 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1364 T1364 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1422 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]