iPTMnet Report for Q7L8J4 (SH3BP5L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7L8J4 / 3BP5L_HUMAN
Protein Name SH3 domain-binding protein 5-like
Gene Name Name: SH3BP5L
Synonyms:KIAA1720;ORFNames:UNQ2766/PRO7133;
Organism Homo sapiens (Human)

PRO ID PR:Q7L8J4
DAG View
PRO Name SH3 domain-binding protein 5-like (human)
Definition An SH3 domain-binding protein 5-like that is encoded in the genome of human.
Short Label hSH3BP5L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7L8J4 (SH3BP5L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T13 Phosphorylation PhosphoSitePlus   UniProt 23186163
S30 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S49 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S350 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S358 Phosphorylation PhosphoSitePlus   UniProt 20068231
S362 Phosphorylation PhosphoSitePlus   UniProt 23186163, 18669648, 24275569, ...19690332, 20068231
S378 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S343 Phosphorylation HPRD 18669648
S350 Phosphorylation HPRD 18669648
S358 Phosphorylation HPRD 19651622, 20068231
S362 Phosphorylation HPRD 19651622, 20166139, 18669648, ...20068231, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S49 P49 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K112 N112 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S142 I142 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S350 F350 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S358 L358 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S362 I362 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]