iPTMnet Report for Q7L7X3 (TAOK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7L7X3 / TAOK1_HUMAN
Protein Name Serine/threonine-protein kinase TAO1
Gene Name Name: TAOK1
Synonyms:KIAA1361,MAP3K16,MARKK;
Organism Homo sapiens (Human)

PRO ID PR:Q7L7X3
DAG View
PRO Name serine/threonine-protein kinase TAO1 (human)
Definition A serine/threonine-protein kinase TAO1 that is encoded in the genome of human.
Short Label hTAOK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7L7X3 (TAOK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163, ...19690332
K21 Ubiquitination PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
Y187 Phosphorylation PhosphoSitePlus
C261 Methylation IEDB 31844290
R269 Methylation PhosphoSitePlus
T288 O-Glycosylation GlyGen 25367160, 30620550
Y309 Phosphorylation PhosphoSitePlus
Y406 Phosphorylation PhosphoSitePlus
S417 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S421 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 18088087, ...16964243, 18220336, 15302935, 18669648, 19369195, 23186163, 19690332
S426 Phosphorylation PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
S445 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 32387766, 18669648, 23186163
S458 Phosphorylation PhosphoSitePlus
T480 Phosphorylation PhosphoSitePlus
T502 Phosphorylation PhosphoSitePlus
K546 Acetylation PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
Y610 Phosphorylation PhosphoSitePlus
T643 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor 17396146
T669 Phosphorylation PhosphoSitePlus   UniProt 19369195
S714 Phosphorylation PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
T734 Phosphorylation PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
T785 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor 17396146
K818 Ubiquitination PhosphoSitePlus
K820 Acetylation PhosphoSitePlus
S839 O-Glycosylation GlyGen 25367160, 30620550
S965 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 23186163, 17081983
S974 Phosphorylation PhosphoSitePlus
R984 Methylation PhosphoSitePlus
S987 Phosphorylation PhosphoSitePlus
S990 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor 17396146
S993 Phosphorylation PhosphoSitePlus
T1001 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 19651622, 18669648
S417 Phosphorylation HPRD 18669648, 20068231
S421 Phosphorylation HPRD 19413330, 18691976, 18088087, ...16964243, 18767875, 15302935, 19664995, 19664994, 18669648, 20068231
S445 Phosphorylation HPRD 18669648, 18212344
S958 Phosphorylation HPRD 17081983
S959 Phosphorylation HPRD 17081983
S965 Phosphorylation HPRD 18088087


Q7L7X3 (TAOK1) as PTM Enzyme



Substrate Site Score Source PMID
P46734 (MAP2K3) S218 Signor 9786855
Q13188 (STK3) T180 neXtProt 22075148
Q7KZI7 (MARK2) T208 neXtProt 14517247
Q9P0L2-1 (MARK1) T215 HPRD 18691976, 14517247, 14976552


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y43 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y107 C107 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R269 G269 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R269 Q269 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y406 C406 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y406 D406 Biomuta DOID:1324 / lung cancer [ cosmic ]
S421 F421 Biomuta DOID:4159 / skin cancer [ cosmic ]
K820 R820 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S958 N958 Biomuta DOID:4159 / skin cancer [ cosmic ]
S974 F974 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S974 Y974 Biomuta DOID:1612 / breast cancer [ cosmic ]