Protein Information

Cytoscape View

UniProt AC / UniProt ID Q7L7L0 / H2A3_HUMAN
Protein Name Histone H2A type 3
Gene Name Name: H2AW
Organism Homo sapiens (Human)

DAG View
PRO Name histone H2A type 3 (human)
Definition A histone H2A type 3 that is encoded in the genome of human.
Short Label hH2AW
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q7L7L0 (H2AW) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
S2 Acetylation UniProt 15823041
S2 Phosphorylation O75582 (RPS6KA5) HPRD   PRO   UniProt 15010469
K6 Acetylation PRO 17709392
K10 Acetylation PRO 18552846, 12937907
K14 Ubiquitination UniProt 22713238, 22980979
K16 Ubiquitination UniProt 22713238, 22980979
S19 Phosphorylation PhosphoSitePlus
Q105 Methylation UniProt 24352239
K119 Acetylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PRO   UniProt 18400894, 16359901, 15386022, ...25470042, 16702407
T121 Phosphorylation PRO   UniProt 19965387, 24140421, 15078818


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045008 (hHIST3H2A/InitMet-/Ac:1) acK6 PRO 17709392
PR:000045009 (hHIST3H2A/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000045010 (hHIST3H2A/InitMet-/Phos:1) pS2 PRO 15010469
PR:000045012 (hHIST3H2A/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000045017 (hHIST3H2A/InitMet-/Phos:2) pT121 PRO 19965387
PR:000047865 (hHIST3H2A/InitMet-/N6AcLys+) ac PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 T2 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S2 C2 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K16 N16 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S19 L19 Biomuta DOID:10534 / stomach cancer [ tcga ]
Q105 H105 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Q105 K105 Biomuta DOID:3571 / liver cancer [ icgc ]