Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7L7L0 / H2A3_HUMAN
Protein Name Histone H2A type 3
Gene Name Name: HIST3H2A
Organism Homo sapiens (Human)

PRO ID PR:Q7L7L0
DAG View
PRO Name histone H2A type 3 (human)
Definition A histone H2A type 3 that is encoded in the genome of human.
Short Label hHIST3H2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7L7L0 (HIST3H2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
S2 Acetylation UniProt 15823041
S2 Phosphorylation O75582 (RPS6KA5) HPRD   PRO   PhosphoSitePlus   UniProt 15010469
K6 Acetylation PRO   PhosphoSitePlus 17709392
K6 Methylation PhosphoSitePlus
K10 Acetylation PRO   PhosphoSitePlus 18552846, 12937907
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination UniProt 22713238, 22980979
K16 Ubiquitination UniProt 22713238, 22980979
S20 Phosphorylation PhosphoSitePlus
R21 Methylation PhosphoSitePlus
R30 Methylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
R82 Methylation PhosphoSitePlus
R89 Methylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Methylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
R100 Methylation PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
Q105 Methylation UniProt 24352239
K119 Acetylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
K120 Sumoylation PhosphoSitePlus
K120 Ubiquitination PRO   PhosphoSitePlus   UniProt 18400894, 25470042, 16359901, ...15386022, 16702407
T121 Phosphorylation PRO   PhosphoSitePlus   UniProt 19965387, 24140421, 15078818
S123 Phosphorylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045008 (hHIST3H2A/InitMet-/Ac:1) acK6 PRO 17709392
PR:000045009 (hHIST3H2A/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000045010 (hHIST3H2A/InitMet-/Phos:1) pS2 PRO 15010469
PR:000045012 (hHIST3H2A/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000045017 (hHIST3H2A/InitMet-/Phos:2) pT121 PRO 19965387
PR:000047858 (hHIST3H2A/InitMet-/Ac:3) acK6 PRO
PR:000047865 (hHIST3H2A/InitMet-/N6AcLys+) ac PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 T2 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S2 C2 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K16 N16 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S20 L20 Biomuta DOID:3571 / liver cancer [ tcga ]
Q105 H105 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Q105 K105 Biomuta DOID:3571 / liver cancer [ icgc ]