iPTMnet Report for Q7L2J0 (MEPCE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7L2J0 / MEPCE_HUMAN
Protein Name 7SK snRNA methylphosphate capping enzyme
Gene Name Name: MEPCE
Synonyms:BCDIN3;
Organism Homo sapiens (Human)

PRO ID PR:Q7L2J0
DAG View
PRO Name 7SK snRNA methylphosphate capping enzyme (human)
Definition A 7SK snRNA methylphosphate capping enzyme that is encoded in the genome of human.
Short Label hMEPCE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7L2J0 (MEPCE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
K21 Sumoylation PhosphoSitePlus
C54 S-Nitrosylation dbSNO 26338901
S57 Phosphorylation PhosphoSitePlus   UniProt 18691976
S60 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...24275569
S69 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...18220336, 18669648, 24275569, 20068231
S76 O-Glycosylation GlyGen 31373491
S78 O-Glycosylation GlyGen 31373491
S78 Phosphorylation PhosphoSitePlus
R86 Methylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
R117 Methylation PhosphoSitePlus
K148 Acetylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 24275569
K163 Ubiquitination PhosphoSitePlus
S175 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983, 18220336
S179 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18220336
S183 Phosphorylation PhosphoSitePlus
T208 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T213 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 19690332, 20068231
S216 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S217 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...24275569, 20068231
K222 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
T245 Phosphorylation phospho.ELM 18669648
S254 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...19369195, 18669648, 24275569, 20068231
K257 Ubiquitination PhosphoSitePlus
T258 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R266 Methylation PhosphoSitePlus
T287 Phosphorylation PhosphoSitePlus
T291 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S300 Phosphorylation PhosphoSitePlus
R304 Methylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
S330 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648
S334 Phosphorylation PhosphoSitePlus
S344 O-Glycosylation GlyGen 31373491
S344 Phosphorylation PhosphoSitePlus   UniProt 24275569
S350 O-Glycosylation GlyGen 31373491
S358 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
R377 Methylation PhosphoSitePlus
K384 Methylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus   UniProt 20068231
K412 Ubiquitination PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
T628 Phosphorylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
Y661 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
Site PTM Type PTM Enzyme Score Source PMID
S57 Phosphorylation HPRD 18691976, 17081983
S60 Phosphorylation HPRD 19413330, 18691976, 17081983, ...16964243, 18767875, 19664995, 18669648, 20068231, 18212344
S69 Phosphorylation HPRD 18691976, 17081983, 19651622, ...18669648, 18707149, 20068231
T75 Phosphorylation HPRD 18691976
S76 Phosphorylation HPRD 18691976
S101 Phosphorylation HPRD 18691976, 20068231
S152 Phosphorylation HPRD 18691976, 18212344, 18767875
S175 Phosphorylation HPRD 18691976, 17081983, 20068231
S179 Phosphorylation HPRD 17081983, 20068231
T208 Phosphorylation HPRD 18767875, 18669648, 16964243, ...20068231
T213 Phosphorylation HPRD 19413330, 16964243, 18767875, ...19664994, 19651622, 18669648, 20068231
S216 Phosphorylation HPRD 19413330, 18691976, 20058876, ...19664994, 19664995, 19651622, 18669648, 18767875, 20166139, 20068231
S217 Phosphorylation HPRD 19413330, 18691976, 16964243, ...18767875, 20058876, 19651622, 18669648, 20166139, 19415658, 20068231
T243 Phosphorylation HPRD 18691976
T245 Phosphorylation HPRD 18669648, 20068231
S254 Phosphorylation HPRD 18691976, 18669648, 18212344, ...20068231
T258 Phosphorylation HPRD 18669648
T291 Phosphorylation HPRD 19413330, 18669648, 20068231
S330 Phosphorylation HPRD 18691976, 18669648, 20068231
S390 Phosphorylation HPRD 18691976, 20068231
S686 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S94 P94 Biomuta DOID:11934 / head and neck cancer [ icgc ]
S101 L101 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R117 W117 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S179 C179 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T243 A243 Biomuta DOID:1324 / lung cancer [ cosmic ]
S254 L254 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S300 A300 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S344 L344 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S369 Y369 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y418 S418 Biomuta DOID:363 / uterine cancer [ icgc ]
K438 T438 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T628 A628 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]