iPTMnet Report for Q7L1W4 (LRRC8D)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7L1W4 / LRC8D_HUMAN
Protein Name Volume-regulated anion channel subunit LRRC8D
Gene Name Name: LRRC8D
Synonyms:LRRC5;ORFNames:UNQ213/PRO239;
Organism Homo sapiens (Human)

PRO ID PR:Q7L1W4
DAG View
PRO Name volume-regulated anion channel subunit LRRC8D (human)
Definition A volume-regulated anion channel subunit LRRC8D that is encoded in the genome of human.
Short Label hLRRC8D
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7L1W4 (LRRC8D) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y17 Phosphorylation HPRD   PhosphoSitePlus 18491316
T68 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T76 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T77 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T106 O-Glycosylation GlyGen 30459171
T114 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T118 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
K128 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
S241 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S242 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S246 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S248 Phosphorylation PhosphoSitePlus
T251 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
T257 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
T312 Phosphorylation HPRD   PhosphoSitePlus 18452278
C354 Methylation IEDB 31844290
S407 Phosphorylation PhosphoSitePlus
C541 Methylation IEDB 31844290
Y566 Phosphorylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
K806 Methylation PhosphoSitePlus
K806 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T106 I106 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K211 E211 Biomuta DOID:363 / uterine cancer [ icgc ]
K211 T211 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S242 N242 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S246 N246 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T251 A251 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S272 N272 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S604 P604 Biomuta DOID:363 / uterine cancer [ cosmic ]
S630 T630 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]