iPTMnet Report for Q7L1T6 (CYB5R4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q7L1T6 / NB5R4_HUMAN
Protein Name Cytochrome b5 reductase 4
Gene Name Name: CYB5R4
Synonyms:NCB5OR;
Organism Homo sapiens (Human)

PRO ID PR:Q7L1T6
DAG View
PRO Name cytochrome b5 reductase 4 (human)
Definition A cytochrome b5 reductase 4 that is encoded in the genome of human.
Short Label hCYB5R4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q7L1T6 (CYB5R4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S14 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
C213 Methylation IEDB 31844290
K277 Ubiquitination PhosphoSitePlus
Y326 Phosphorylation PhosphoSitePlus
Y347 Phosphorylation IEDB 32387766
T361 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S154 G154 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T157 A157 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T157 R157 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y326 H326 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y347 C347 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S471 L471 Biomuta DOID:4159 / skin cancer [ cosmic ]
S476 P476 Biomuta DOID:9256 / colorectal cancer [ cosmic ]